This paper proposes a novel dual-drive hydrostatic lead-screw system (DDHLS). The design enables a lower feed speed and a better transmission performance than the conventional hydrostatic lead screw (HLS). Considering the nut-misalignment, the lubricating mathematical model of the DDHLS is established based on the perturbation method and solved by the finite difference method. The influences of the nut-radial-displacement, the nut-tilt, and the dual-drivable design on the transmission performance of the DDHLS are researched. The results show the nut-misalignment can regularly reduce or increase the axial load capacity, the axial stiffness coefficient, and the axial damping coefficient. Significantly, the dual-drivable design can improve the axial load capacity and the axial stiffness coefficient while hardly affects the axial damping coefficient.