The study of thermal hydraulics of a hexagonal sub-assembly is essential to ensure the safe operation of liquid metal cooled fast reactors. Identifying the dryout location in fuel sub-assembly (FSA) is a precursor to the determination of safe Critical Heat Flux (CHF) margins. In this study, a sub-channel analysis code coupled with a film thickness model is employed to predict the CHF location in a hexagonal sub-assembly. A simple post-CHF heat transfer model is proposed and validated against the experimental data. The nature of flow resistance changes and operating conditions would significantly influence the occurrence of CHF. To this end, the effect of blockage (0.0 ≤ b ≤ 0.3) and axial power distribution (APD) on CHF is systematically investigated in a hexagonal sub-assembly. It was observed that the presence of blockage causes coolant flow maldistribution which results in an early occurrence of CHF for higher mass flux (G > 1500 kgm−2s−1) and lower inlet subcooling (ΔTsub ≤ 30 K) conditions for b = 0.3. Furthermore, a comparative study of uniform and sinusoidal heat flux distributions is performed. It was noticed that sinusoidal APD causes the early occurrence of CHF compared to uniform APD.