An experimental investigation of condensation and evaporation heat transfer characteristics was performed in 15.88-mm-OD and 12.7-mm-OD smooth and three-dimensional enhanced tubes (1EHT, 3EHT) using R134A and R410A as the working fluid. The enhanced surface of the 1EHT tube is made up of dimples and a series of petal arrays; while the 3EHT tube is made up of rectangular cavities. Evaluations are performed at a saturation temperature of 45 °C, over the quality range of 0.8–0.2 for condensation; while for evaporation the saturation temperature was 6 °C and the quality ranged from 0.2 to 0.8. For condensation, the enhancement ratio (enhanced tube/smooth tube) of the heat transfer coefficients was 1.42–1.95 for the mass flux ranging from 80 to 200 kg/m2s; while for evaporation, the heat transfer enhancement ratio is 1.05–1.42 for values of mass flux that range from 50 to 180 kg/m2s. Furthermore, the 1EHT tube provides the best condensation and evaporation heat transfer performance, for both working fluids at the mass flux considered. This performance is due to the dimples in the enhanced surface that produce interface turbulence; additionally, the increased surface roughness causes additional disturbances and secondary flows near the boundary, producing higher heat fluxes. The main objective of this study was to evaluate the heat transfer enhancement of two enhanced tubes when using R134A and R410A as a function of mass flux, saturation temperature, and tube diameter. As a result of this study, it was determined that the heat transfer coefficient decreases with an increase in saturation temperature and tube diameter.