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Marvin J. Slepian
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Journal Articles

In Memoriam: Shmuel Einav, 1942–2022

Danny Bluestein, C. Forbes Dewey, Jr., David Elad, Morteza (Mory) Gharib, Roger D. Kamm, Barry B. Lieber, Susan S. Margulies, Marvin J. Slepian, John Tarbell, Sheldon (Shelly) Weinbaum
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: In Memoriam
J Biomech Eng. August 2022, 144(8): 080101.
Paper No: BIO-22-1168
https://doi.org/10.1115/1.4054797
Published Online: June 23, 2022
View Article titled, In Memoriam: Shmuel Einav, 1942–2022
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Topics: Bioengineering, Biomedical engineering, Biomedicine, Cardiovascular system, Casting, Engineering teachers, Diseases, Flow (Dynamics), Mentoring, Collaboration
Journal Articles

Visions of TAVR Future: Development and Optimization of a Second Generation Novel Polymeric TAVR

Brandon Kovarovic, Ryan Helbock, Kyle Baylous, Oren M. Rotman, Marvin J. Slepian, Danny Bluestein
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2022, 144(6): 061008.
Paper No: BIO-21-1420
https://doi.org/10.1115/1.4054149
Published Online: April 6, 2022
View Article titled, Visions of TAVR Future: Development and Optimization of a Second Generation Novel Polymeric TAVR
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Topics: Design, Optimization, Stents, Valves, Stress, Shapes, Durability, Biological tissues, Polymers
Journal Articles

Design, Modeling, and Experimental Characterization of A Valveless Pulsatile Flow Mechanical Circulatory Support Device

Mengtang Li, Ye Chen, Marvin J. Slepian, Joseph Howard, Seth Thomas, Eric J. Barth
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Research-Article
J. Med. Devices. June 2021, 15(2): 021009.
Paper No: MED-20-1150
https://doi.org/10.1115/1.4049560
Published Online: February 4, 2021
View Article titled, Design, Modeling, and Experimental Characterization of A Valveless Pulsatile Flow Mechanical Circulatory Support Device
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Topics: Design, Engineering prototypes, Flow (Dynamics), Pulsatile flow, Pumps, Blood, Shear stress
Journal Articles

Bond Graph Modeling of Mechanical Circulatory Support Device—Cardiovascular System Interactions

Mengtang Li, Marvin J. Slepian, Eric J. Barth
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. August 2020, 142(8): 084501.
Paper No: BIO-19-1288
https://doi.org/10.1115/1.4045812
Published Online: March 4, 2020
View Article titled, Bond Graph Modeling of Mechanical Circulatory Support Device—Cardiovascular System Interactions
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Topics: Artificial hearts, Cardiovascular system, Modeling
Journal Articles

Comparative Fluid–Structure Interaction Analysis of Polymeric Transcatheter and Surgical Aortic Valves' Hemodynamics and Structural Mechanics

Ram P. Ghosh, Gil Marom, Oren M. Rotman, Marvin J. Slepian, Saurabh Prabhakar, Marc Horner, Danny Bluestein
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2018, 140(12): 121002.
Paper No: BIO-17-1507
https://doi.org/10.1115/1.4040600
Published Online: September 25, 2018
View Article titled, Comparative Fluid–Structure Interaction Analysis of Polymeric Transcatheter and Surgical Aortic Valves' Hemodynamics and Structural Mechanics
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Topics: Flow (Dynamics), Fluid structure interaction, Valves, Hemodynamics, Surgery, Stress
Journal Articles

Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics and Molecular Dynamics

Danny Bluestein, João S. Soares, Peng Zhang, Chao Gao, Seetha Pothapragada, Na Zhang, Marvin J. Slepian, Yuefan Deng
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Frontiers Abstracts
J. Med. Devices. December 2013, 7(4): 024502.
Paper No: MED-13-1211
https://doi.org/10.1115/1.4027347
Published Online: April 28, 2014
View Article titled, Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics and Molecular Dynamics
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Topics: Flow (Dynamics), Molecular dynamics, Multiscale modeling, Particle dynamics, Platelets
Proceedings Papers

Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics (DPD) and Molecular Dynamics (MD)

Danny Bluestein, João S. Soares, Peng Zhang, Chao Gao, Seetha Pothapragada, Na Zhang, Marvin J. Slepian, Yuefan Deng
Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T07A005, September 11–13, 2013
Publisher: American Society of Mechanical Engineers
Paper No: FMD2013-16176
https://doi.org/10.1115/FMD2013-16176
View Paper titled, Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics (DPD) and Molecular Dynamics (MD)
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Topics: Flow (Dynamics), Molecular dynamics, Multiscale modeling, Particle dynamics, Platelets, Thrombosis, Blood, Blood flow, Erythrocytes, Fluids
Proceedings Papers

Design Optimization of a Novel Polymeric Prosthetic Heart Valve and a Ventricular Assist Device via Device Thrombogenicity Emulation

Thomas E. Claiborne, Wei-Che Chiu, Marvin J. Slepian, Danny Bluestein
Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T10A046, September 11–13, 2013
Publisher: American Society of Mechanical Engineers
Paper No: FMD2013-16173
https://doi.org/10.1115/FMD2013-16173
View Paper titled, Design Optimization of a Novel Polymeric Prosthetic Heart Valve and a Ventricular Assist Device via Device Thrombogenicity Emulation
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Topics: Design, Heart valve prostheses, Optimization, Ventricular assist devices, Platelets, Artificial hearts, Blood, Computer simulation, Die cutting, Hemodynamics
Proceedings Papers

Platelet Activity State in Human, Bovine, and Ovine Species Under Constant Shear Stress: A Comparative Study

Phat L. Tran, Valerie M. Merkle, Tracy DeCook, Marcus Hutchinson, Jawaad Sheriff, Danny Bluestein, Marvin J. Slepian
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT03A006, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14825
https://doi.org/10.1115/SBC2013-14825
View Paper titled, Platelet Activity State in Human, Bovine, and Ovine Species Under Constant Shear Stress: A Comparative Study
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Topics: Platelets, Shear stress, Artificial hearts, Blood, Bridges (Structures), Cardiovascular devices, Design, Heart failure, Patient treatment, Ventricular assist devices
Proceedings Papers

In Vitro Evaluation of Shear-Induced Platelet Activation in the MicroMed DeBakey Ventricular Assist Device With Antiplatelet Therapy

Jawaad Sheriff, Gaurav Girdhar, Sheela George, Wei-Che Chiu, Bryan E. Lynch, Jolyon Jesty, Marvin J. Slepian, Danny Bluestein
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT05A003, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14088
https://doi.org/10.1115/SBC2013-14088
View Paper titled, In Vitro Evaluation of Shear-Induced Platelet Activation in the MicroMed DeBakey Ventricular Assist Device With Antiplatelet Therapy
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Topics: Patient treatment, Platelets, Shear (Mechanics), Ventricular assist devices, Thrombosis, Bridges (Structures), Design, Flow (Dynamics), Heart failure, Optimization
Proceedings Papers

Platelet Activity of Coaxial Electrospun Scaffolds for Applications in Cardiovascular Tissue Engineering

Valerie M. Merkle, Marcus Hutchinson, Phat L. Tran, Jawaad Sheriff, Danny Bluestein, Xiaoyi Wu, Marvin J. Slepian
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT17A027, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14780
https://doi.org/10.1115/SBC2013-14780
View Paper titled, Platelet Activity of Coaxial Electrospun Scaffolds for Applications in Cardiovascular Tissue Engineering
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Topics: Cardiovascular system, Platelets, Tissue engineering, Ethanol, Gelatin, Adhesion, Biocompatibility, Design, Drug delivery systems, Endothelial cells
Proceedings Papers

In Vitro Biocompatibility of Coaxial Electrospun Scaffolds for Cardiovascular Tissue Engineering

Valerie M. Merkle, Kaitlyn R. Ammann, Katrina J. DeCook, Phat L. Tran, Marvin J. Slepian, Xiaoyi Wu
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT17A028, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14790
https://doi.org/10.1115/SBC2013-14790
View Paper titled, In Vitro Biocompatibility of Coaxial Electrospun Scaffolds for Cardiovascular Tissue Engineering
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Topics: Biocompatibility, Cardiovascular system, Tissue engineering, Nanofibers, Gelatin, Endothelial cells, Ethanol, Muscle, Polymers, Adhesion
Proceedings Papers

Multiscale Modeling of Flow Induced Thrombogenicity Using Dissipative Particle Dynamics and Molecular Dynamics

Danny Bluestein, João S. Soares, Peng Zhang, Chao Gao, Seetha Pothapragada, Na Zhang, Marvin J. Slepian, Yuefan Deng
Proc. ASME. NEMB2013, ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, V001T05A006, February 4–6, 2013
Publisher: American Society of Mechanical Engineers
Paper No: NEMB2013-93094
https://doi.org/10.1115/NEMB2013-93094
View Paper titled, Multiscale Modeling of Flow Induced Thrombogenicity Using Dissipative Particle Dynamics and Molecular Dynamics
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Topics: Flow (Dynamics), Molecular dynamics, Multiscale modeling, Particle dynamics, Platelets, Thrombosis, Blood, Blood flow, Erythrocytes, Fluids
Proceedings Papers

Interaction With Nanoscale Topography: The Use of Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces To Modulate Physiological Focal Adhesions in Endothelial Cells

Phat L. Tran, Jessica R. Gamboa, Katherine E. McCracken, Jeong-Yeol Yoon, Marvin J. Slepian
Proc. ASME. NEMB2013, ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology, V001T07A006, February 4–6, 2013
Publisher: American Society of Mechanical Engineers
Paper No: NEMB2013-93345
https://doi.org/10.1115/NEMB2013-93345
View Paper titled, Interaction With Nanoscale Topography: The Use of Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces To Modulate Physiological Focal Adhesions in Endothelial Cells
Open the PDF for Interaction With Nanoscale Topography: The Use of Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces To Modulate Physiological Focal Adhesions in Endothelial Cells in another window
Topics: Bearings, Endothelial cells, Nanoparticles, Nanoscale phenomena, Physiology, Adhesion, Adhesives, Biomaterials, Flow (Dynamics), Blood
Proceedings Papers

Functional Endoluminal Paving (FELP): Thermoforming, Biodegradation, and Mechanical Properties of a Novel Polymer Graft for Abdominal Aortic Aneurysms

John H. Ashton, James A. M. Mertz, Megan J. Alexander, Marvin J. Slepian, Joseph L. Mills, Jonathan P. Vande Geest
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 905-906, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19463
https://doi.org/10.1115/SBC2010-19463
View Paper titled, Functional Endoluminal Paving (FELP): Thermoforming, Biodegradation, and Mechanical Properties of a Novel Polymer Graft for Abdominal Aortic Aneurysms
Open the PDF for Functional Endoluminal Paving (FELP): Thermoforming, Biodegradation, and Mechanical Properties of a Novel Polymer Graft for Abdominal Aortic Aneurysms in another window
Topics: Aneurysms, Biodegradation, Mechanical properties, Polymers, Anatomy, Drugs, Failure, Maintenance, Stents
Proceedings Papers

In-Vitro Thrombogenicity Assessment of Mechanical Circulatory Support Devices and Prosthetic Heart Valves

Thomas E. Claiborne, Gaurav Girdhar, Jawaad Sheriff, Jolyon Jesty, Marvin J. Slepian, Robert Benkowski, Leonard Pinchuk, Danny Bluestein
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 115-116, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19287
https://doi.org/10.1115/SBC2010-19287
View Paper titled, In-Vitro Thrombogenicity Assessment of Mechanical Circulatory Support Devices and Prosthetic Heart Valves
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Topics: Heart valve prostheses, Platelets, Artificial hearts, Blood, Bridges (Structures), Engineering prototypes, Flow (Dynamics), Heart failure, Impellers, Patient treatment
Journal Articles

In Vitro Evaluation of a Novel Hemodynamically Optimized Trileaflet Polymeric Prosthetic Heart Valve

Thomas E. Claiborne, Jawaad Sheriff, Maximilian Kuetting, Ulrich Steinseifer, Marvin J. Slepian, Danny Bluestein
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2013, 135(2): 021021.
Paper No: BIO-12-1474
https://doi.org/10.1115/1.4023235
Published Online: February 7, 2013
View Article titled, In Vitro Evaluation of a Novel Hemodynamically Optimized Trileaflet Polymeric Prosthetic Heart Valve
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Topics: Biological tissues, Design, Platelets, Valves, Finite element analysis, Engineering prototypes, Hydrodynamics, Polymers, Testing, Heart valve prostheses