This paper presents a novel design approach to systematically synthesize available configurations for dedicated hybrid transmission (DHT) systems subject to design constraints and required operation modes by using simple planetary gear sets (PGSs). The configuration synthesis process includes two main steps. The first step is the synthesis of the PGSs by synthesizing all the components to a simple PGS subject to the design constraints. The second step is to combine the structural and shift elements into all configurations and detect those meeting the requirements with the mechanical and operation mode constraints. By applying the proposed design approach, the configurations of the Toyota’s hybrid systems (THSs) and Voltec-II prove the feasibility of the method. Furthermore, several new DHT configurations are synthesized under the new design conditions. The proposed design approach is capable of systematically synthesizing new DHT systems with multiple PGSs, variable design constraints, and expected modes.