This study presents a novel performance evaluation of the commercially available LS-2 collector operating with an oil-based olive leaf-synthesized nanofluid. The nanoparticles were synthesized experimentally from olive leaf extracts (OLEs): OLE-ZVI and OLE-TiO 2 . The thermophysical properties of the nanoparticles were then added to Syltherm-800 thermal oil, and its performance on the parabolic trough solar collector (PTC) was evaluated numerically. The PTC under study was modeled on the engineering equation solver (EES) and validated thermally with results found in the literature. The synthesized nanoparticles were also found to possess anticorrosion properties, nontoxic, and less expensive to produce when compared to commercially available ones. The use of the nanofluids (Syltherm-800/OLE-ZVI and Syltherm-800/OLE-TiO 2 ) was evaluated against the parameters of thermal and exergetic efficiencies, heat transfer coefficient, thermal losses, and pressure drop. The study shows that an enhancement in thermal performance of 0.51% and 0.48% was achieved by using Syltherm-800/OLE-ZVI and Syltherm-800/OLE-TiO 2 nanofluids, respectively. A heat transfer coefficient enhancement of 42.9% and 51.2% was also observed for Syltherm-800/OLE-TiO 2 and Syltherm-800/OLE-ZVI nanofluids, respectively. Also, a mean variation in pressure drop of 11.5% was observed by using the nanofluids at a nanoparticle volumetric concentration of 3%. A comparison of the results of this study with related literature shows that the proposed nanofluids outperform those found in literature.