The United States (U.S.) Department of Energy (DOE) / National Nuclear Security Administration’s (NNSA) Global Threat Reduction Initiative (GTRI) supports both U.S. and international threat reduction goals by securing vulnerable nuclear and radiological material located at civilian sites throughout the world. GTRI’s approach to reducing the threat posed by vulnerable, high-activity radioactive sources includes removing and disposing of orphan or disused radioactive sources; implementing physical security upgrades at civilian sites containing radioactive sources; and establishing a cooperative sustainability program at sites to ensure that upgrades are maintained. For many years GTRI has collaborated successfully with the Russian Federation and international partners to improve radiological security in Russia. This paper provides a synopsis of GTRI’s accomplishments and cooperation with Russia in the following areas: 1.) recovering and disposing of orphan and disused radioactive sources, 2.) recovering and disposing of radioisotope thermoelectric generators (RTGs), and 3.) providing physical security upgrades at civilian sites that contain vulnerable radiological material.