Glass fiber tape reinforced polyethylene (GFTRP) pipes are widely used for the transportation of oil and high pressure gas due to their good load bearing capacity and environmental adaptability. Delamination defect is one of the most common defects of GFTRP pipes during manufacturing and service. This paper investigates the load bearing capacity of GFTRP pipe with interlayer delamination defect in between glass fiber tapes, via a combined experimental and numerical method. In the burst experiments, GFTRP pipes with layup of [±55°]12 were prepared with the artificial delamination defects set in between the 6th and 7th plies. In the numerical model, we used progressive damage model and cohesive element method to analysis the failure of GFTRP pipe with interlayer delamination defect. The results show that both the widths and axial locations of interlayer delamination defects will affect the burst pressure of GFTRP pipe, and the numerical analysis results are in good consistency with experiments. Ultimately, the influence of defect width and location on the burst pressure of GFTRP pipe was discussed in detail.