The aim of this study was to assess radio activity and elements levels of Ebrié lagoon water in Abidjan, Côte d'Ivoire. Eight bottles of water from Ebrié lagoon were taken for the study. This study was achieved by measuring of the activity concentration of 238U, 40K, and 232Th in Ebrié lagoon water samples using gamma spectrometry. Elements contents were determined too by Absorption Atomic Spectrometry technique. The activity concentrations of these radionuclides show that populations in these townships-villages are permanently exposed to diseases caused by the ionizing rays. The elemental analysis showed that the potential source of the pollutants is anthropogenic, intrusion from industrial and agricultural activities, materials and lubricants used near the lagoon are important factors of the pollution in this lagoon.