Here, we report a threshold limit value (TLV) of on-chip cytotoxicity of Nepali Chiya, the Nepali traditional black tea. To demonstrate our proof-of-concept validation, we used the active sealing chip with serial dilution that can directly perform on-chip cytotoxicity testing onto the cells cultured in a petri dish. In our experiments, the TLV for mortality on HeLa cells was observed as 400 μg/ml for Nepali Chiya extract. We believe this approach would be a rapid and simple method for on-chip TLV screening of potability of tea extract at the laboratory level, and furthermore as a new potential drug supplement in pharmaceutical industries.
On-Chip Cytotoxicity Testing of Nepali Chiya Extract
Manuscript received September 15, 2015; final manuscript received March 22, 2016; published online May 3, 2016. Assoc. Editor: Feng Xu.
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Kim, S., Hyuk Jang, I., and Gu Lee, W. (May 3, 2016). "On-Chip Cytotoxicity Testing of Nepali Chiya Extract." ASME. J. Nanotechnol. Eng. Med. November 2015; 6(4): 041004. https://doi.org/10.1115/1.4033194
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