Bioprinting is an emerging technology to fabricate artificial tissues and organs through additive manufacturing of living cells in a tissues-specific pattern by stacking them layer by layer. Two major approaches have been proposed in the literature: bioprinting cells in a scaffold matrix to support cell proliferation and growth, and bioprinting cells without using a scaffold structure. Despite great progress, particularly in scaffold-based approaches along with recent significant attempts, printing large-scale tissues and organs is still elusive. This paper demonstrates recent significant attempts in scaffold-based and scaffold-free tissue printing approaches, discusses the advantages and limitations of both approaches, and presents a conceptual framework for bioprinting of scale-up tissue by complementing the benefits of these approaches.
Scaffold-Based or Scaffold-Free Bioprinting: Competing or Complementing Approaches?
Manuscript received April 12, 2015; final manuscript received April 16, 2015; published online September 29, 2015. Assoc. Editor: Abraham Quan Wang.
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Ozbolat, I. T. (September 29, 2015). "Scaffold-Based or Scaffold-Free Bioprinting: Competing or Complementing Approaches?." ASME. J. Nanotechnol. Eng. Med. May 2015; 6(2): 024701. https://doi.org/10.1115/1.4030414
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