We aimed to investigate 3,5,3′-triiodothyroacetic acid (TRIAC) effects on intact and atrophic skin induced by glucocorticoids (GCs) in rats and the effects induced by nanoencapsulation. The effects of TRIAC and nanoencapsulated TRIAC were evaluated on intact and atrophic skin in TRIAC experiment and nanoencapsulated TRIAC experiment, respectively. Both experiments had two phases: phase I, cutaneous atrophy was induced; phase II, TRIAC or nanoencapsulated TRIAC was administrated. Our results showed that topical use of TRIAC with or without nanoencapsulation was able to reverse cutaneous atrophy. Nanoencapsulated TRIAC showed less systemic changes than TRIAC; therefore, it is possibly a safer drug for topical administration.

References

References
1.
Brazzini
,
B.
, and
Pimpinelli
,
N.
,
2002
, “
New and Established Topical Corticosteroids in Dermatology: Clinical Pharmacology and Therapeutic Use
,”
Am. J. Clin. Dermatol.
,
3
(
1
), pp.
47
58
.10.2165/00128071-200203010-00005
2.
Seguro
,
L. P.
,
Rosario
,
C.
, and
Shoenfeld
,
Y.
,
2013
, “
Long-Term Complications of Past Glucocorticoid Use
,”
Autoimmun. Rev.
,
12
(
5
), pp.
629
632
.10.1016/j.autrev.2012.12.002
3.
LoPresti
,
J. S.
,
Eigen
,
A.
,
Kaptein
,
E.
,
Anderson
,
K. P.
,
Spencer
,
C. A.
, and
Nicoloff
,
J. T.
,
1989
, “
Alterations in 3,3′,5′-Triiodothyronine Metabolism in Response to Propylthiouracil, Dexamethasone, and Thyroxine Administration in Man
,”
J. Clin. Invest.
,
84
(
5
), pp.
1650
1656
.10.1172/JCI114343
4.
Antonini
,
D.
,
Sibilio
,
A.
,
Dentice
,
M.
, and
Missero
,
C.
,
2013
, “
An Intimate Relationship Between Thyroid Hormone and Skin: Regulation of Gene Expression
,”
Front. Endocrinol.
,
4
, p.
104
.10.3389/fendo.2013.00104
5.
Nunes
,
M. T.
,
2003
, “
Thyroid Hormones: Mechanism of Action and Biological Significance
,”
Arq. Bras. Endocrinol. Metab.
,
47
(
6
), pp.
639
643
.10.1590/S0004-27302003000600004
6.
Yazdanparast
,
P.
,
Carlsson
,
B.
,
Oikarinen
,
A.
,
Risteli
,
J.
,
Lavin
,
T.
, and
Faergemann
,
J.
,
2006
, “
Action of Topical Thyroid Hormone Analogue, Triiodothyroacetic Acid in Reversing Glucocorticoid Induced Skin Atrophy in Humans
,”
Thyroid
,
16
(
11
), pp.
1157
1162
.10.1089/thy.2006.16.1157
7.
Brent
,
G. A.
,
2012
, “
Mechanisms of Thyroid Hormone Action
,”
J. Clin. Invest.
,
122
(
9
), pp.
3035
3043
.10.1172/JCI60047
8.
Contreras-Jurado
,
C.
,
García-Serrano
,
L.
,
Gómez-Ferrería
,
M.
,
Costa
,
C.
,
Paramio
,
J. M.
, and
Aranda
,
A.
,
2011
, “
The Thyroid Hormone Receptors as Modulators of Skin Proliferation and Inflammation
,”
J. Biol. Chem.
,
286
(
27
), pp.
24079
24088
.10.1074/jbc.M111.218487
9.
Safer
,
J. D.
,
2011
, “
Thyroid Hormone Action on Skin
,”
Dermatoendocrinology
,
3
(
3
), pp.
211
215
.10.4161/derm.3.3.17027
10.
Gloss
,
B.
,
Giannocco
,
G.
,
Swanson
,
E. A.
,
Moriscot
,
A. S.
,
Chiellini
,
G.
,
Scanlan
,
T.
,
Baxter
,
J. D.
, and
Dillmann
,
W. H.
,
2005
, “
Different Configurations of Specific Thyroid Hormone Response Elements Mediate Opposite Effects of Thyroid Hormone and GC-1 on Gene Expression
,”
Endocrinology
,
146
(
11
), pp.
4926
4933
.10.1210/en.2005-0631
11.
Cheng
,
S. Y.
,
Leonard
,
J. L.
, and
Davis
,
P. J.
,
2010
, “
Molecular Aspects of Thyroid Hormone Actions
,”
Endocr. Rev.
,
31
(
2
), pp.
139
170
.10.1210/er.2009-0007
12.
Dumitrescu
,
A. M.
, and
Refetoff
,
S.
, “
Novel Biological and Clinical Aspects of Thyroid Hormone Metabolism
,”
Endocr. Dev.
,
10
, pp.
127
139
.10.1159/000106824
13.
Martínez
,
L.
,
Nascimento
,
A. S.
,
Nunes
,
F. M.
,
Phillips
,
K.
,
Aparicio
,
R.
,
Dias
,
S. M.
,
Figueira
,
A. C.
,
Lin
,
J. H.
,
Nguyen
,
P.
,
Apriletti
,
J. W.
,
Neves
,
F. A.
,
Baxter
,
J. D.
,
Webb
,
P.
,
Skaf
,
M. S.
, and
Polikarpov
,
I.
,
2009
, “
Gaining Ligand Selectivity in Thyroid Hormone Receptors Via Entropy
,”
Proc. Natl. Acad. Sci. U.S.A.
,
106
(
49
), pp.
20717
20722
.10.1073/pnas.0911024106
14.
Baxter
,
J. D.
, and
Webb
,
P.
,
2009
, “
Thyroid Hormone Mimetics: Potential Applications in Atherosclerosis, Obesity and Type 2 Diabetes
,”
Nat. Rev. Drug Discov.
,
8
(
4
), pp.
308
320
.10.1038/nrd2830
15.
Faergemann
,
J.
,
Särnhult
,
T.
,
Hedner
,
E.
,
Carlsson
,
B.
,
Lavin
,
T.
,
Zhao
,
X. H.
, and
Sun
,
X. Y.
,
2002
, “
Dose-Response Effects of Tri-Iodothyroacetic Acid (Triac) and Other Thyroid Hormone Analogues on Glucocorticoid-Induced Skin Atrophy in the Haired Mouse
,”
Acta Derm. Venereol.
,
82
(
3
), pp.
179
183
.10.1080/00015550260132451
16.
Yazdanparast
,
P.
,
Carlsson
,
B.
,
Oikarinen
,
A.
,
Risteli
,
J.
, and
Faergemann
,
J.
,
2004
, “
A Thyroid Hormone Analogue, Triiodothyroacetic Acid, Corrects Corticosteroid-Downregulated Collagen Synthesis
,”
Thyroid
,
14
(
5
), pp.
345
353
.10.1089/105072504774193168
17.
Kalia
,
Y. N.
, and
Guy
,
R. H.
,
2001
, “
Modeling Transdermal Drug Release
,”
Adv. Drug Deliv. Rev.
,
48
(
2–3
), pp.
159
172
.10.1016/S0169-409X(01)00113-2
18.
Shaffer
,
C.
,
2005
, “
Nanomedicine Transforms Drug Delivery
,”
Drug Discov. Today
,
10
(
23–24
), pp.
1581
1582
.10.1016/S1359-6446(05)03654-8
19.
Yih
,
T. C.
, and
Al-Fandi
,
M.
,
2006
, “
Engineered Nanoparticles as Precise Drug Delivery Systems
,”
J. Cell Biochem.
,
97
(
6
), pp.
1184
1190
.10.1002/jcb.20796
20.
Müller
,
R. H.
,
Radtke
,
M.
, and
Wissing
,
S. A.
,
2002
, “
Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) in Cosmetic and Dermatological Preparations
,”
Adv. Drug Deliv. Rev.
,
54
(
Suppl 1
), pp.
S131
S155
.10.1016/S0169-409X(02)00118-7
21.
Alvarez-Román
,
R.
,
Naik
,
A.
,
Kalia
,
Y. N.
,
Guy
,
R. H.
, and
Fessi
,
H.
,
2004
, “
Enhancement of Topical Delivery From Biodegradable Nanoparticles
,”
Pharm. Res.
,
21
(
10
), pp.
1818
1825
.10.1023/B:PHAM.0000045235.86197.ef
22.
Guterres
,
S. S.
,
Alves
,
M. P.
, and
Pohlmann
,
A. R.
,
2007
, “
Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications
,”
Drug Target Insights
,
2
, pp.
147
157
.
23.
Alvarez-Román
,
R.
,
Naik
,
A.
,
Kalia
,
Y. N.
,
Guy
,
R. H.
, and
Fessi
,
H.
,
2004
, “
Skin Penetration and Distribution of Polymeric Nanoparticles
,”
J. Control. Release
,
99
(
1
), pp.
53
62
.10.1016/j.jconrel.2004.06.015
24.
Couvreur
,
P.
,
Barratt
,
G.
,
Fattal
,
E.
,
Legrand
,
P.
, and
Vauthier
,
C.
,
2002
, “
Nanocapsule Technology: A Review
,”
Crit. Rev. Ther. Drug Carrier Syst.
,
19
(
2
), pp.
99
134
.10.1615/CritRevTherDrugCarrierSyst.v19.i2.10
25.
Nagavarma
,
B. V. N.
,
Yadav
,
H. K. S.
,
Ayaz
,
A.
,
Vasudha
,
L. S.
, and
Shivakumar
,
H. G.
,
2012
, “
Different Techniques for Preparation of Polymeric Nanoparticles—A Review
,”
Asian J. Pharm. Clin. Res.
,
5
(
3
), pp.
16
23
. Available at: http://www.ajpcr.com/Vol5Suppl3/1128.pdf
26.
Gonzalo
,
T.
,
Lollo
,
G.
,
Garcia-Fuentes
,
M.
,
Torres
,
D.
,
Correa
,
J.
,
Riguera
,
R.
,
Fernandez-Megia
,
E.
,
Calvo
,
P.
,
Aviles
,
P.
,
Jose Guillen
,
M.
, and
Jose Alonso
,
M.
,
2013
, “
A New Potential Nano-Oncological Therapy Based on Polyamino Acid Nanocapsules
,”
J. Control. Release
,
169
(
1–2
), pp.
10
16
.10.1016/j.jconrel.2013.03.037
27.
Wischke
,
C.
, and
Schwendeman
,
S. P.
,
2008
, “
Principles of Encapsulating Hydrophobic Drugs in PLA/PLGA Microparticles
,”
Int. J. Pharm.
,
364
(
2
), pp.
298
327
.10.1016/j.ijpharm.2008.04.042
28.
Kamaly
,
N.
,
Xiao
,
Z.
,
Valencia
,
P. M.
,
Radovic-Moreno
,
A. F.
, and
Farokhzad
,
O. C.
,
2012
, “
Targeted Polymeric Therapeutic Nanoparticles: Design, Development and Clinical Translation
,”
Chem. Soc. Rev.
,
41
(
7
), pp.
2971
3010
.10.1039/c2cs15344k
29.
Haapasaari
,
K. M.
,
Risteli
,
J.
, and
Oikarinen
,
A.
,
1996
, “
Recovery of Human Skin Collagen Synthesis After Short-Term Topical Corticosteroid Treatment and Comparison Between Young and Old Subjects
,”
Br. J. Dermatol.
,
135
(
1
), pp.
65
69
.10.1111/j.1365-2133.1996.tb03609.x
30.
Oishi
,
Y.
,
Fu
,
Z. W.
,
Ohnuki
,
Y.
,
Kato
,
H.
, and
Noguchi
,
T.
,
2002
, “
Molecular Basis of the Alteration in Skin Collagen Metabolism in Response to in Vivo Dexamethasone Treatment: Effects on the Synthesis of Collagen Type I and III, Collagenase, and Tissue Inhibitors of Metalloproteinases
,”
Br. J. Dermatol.
,
147
(
5
), pp.
859
868
10.1046/j.1365-2133.2002.04949.x
31.
Moreno
,
M.
,
de Lange
,
P.
,
Lombardi
,
A.
,
Silvestri
,
E.
,
Lanni
,
A.
, and
Goglia
,
F.
,
2008
, “
Metabolic Effects of Thyroid Hormone Derivatives
,”
Thyroid
,
18
(
2
), pp.
239
253
.10.1089/thy.2007.0248
32.
Medina-Gomez
,
G.
,
Hernàndez
,
A.
,
Calvo
,
R. M.
,
Martin
,
E.
, and
Obregón
,
M. J.
,
2003
, “
Potent Thermogenic Action of Triiodothyroacetic Acid in Brown Adipocytes
,”
Cell Mol. Life Sci.
,
60
(
9
), pp.
1957
1967
.10.1007/s00018-003-3158-9
33.
Medina-Gomez
,
G.
,
Calvo
,
R. M.
, and
Obregon
,
M. J.
,
2008
, “
Thermogenic Effect of Triiodothyroacetic Acid at Low Doses in Rat Adipose Tissue Without Adverse Side Effects in the Thyroid Axis
,”
Am. J. Physiol. Endocrinol. Metab.
,
294
(
4
), pp.
E688
E697
.10.1152/ajpendo.00417.2007
34.
Anzai
,
R.
,
Adachi
,
M.
,
Sho
,
N.
,
Muroya
,
K.
,
Asakura
,
Y.
, and
Onigata
,
K.
,
2012
, “
Long-Term 3,5,3′-Triiodothyroacetic Acid Therapy in a Child With Hyperthyroidism Caused by Thyroid Hormone Resistance: Pharmacological Study and Therapeutic Recommendations
,”
Thyroid
,
22
(
10
), pp.
1069
1075
.10.1089/thy.2011.0450
35.
Safer
,
J. D.
,
Fraser
,
L. M.
,
Ray
,
S.
, and
Holick
,
M. F.
,
2011
, “
Topical Triiodothyronine Stimulates Epidermal Proliferation, Dermal Thickening, and Hair Growth in Mice and Rats
,”
Thyroid
,
11
(
8
), pp.
717
724
.10.1089/10507250152484547
36.
Yazdanparast
,
P.
,
Carlsson
,
B.
,
Sun
,
X. Y.
,
Zhao
,
X. H.
,
Hedner
,
T.
, and
Faergemann
,
J.
,
2006
, “
Action of Topical Thyroid Hormone Analogues on Glucocorticoid-Induced Skin Atrophy in Mice
,”
Thyroid
,
16
(
3
), pp.
273
280
.10.1089/thy.2006.16.273
37.
Zhang
,
B.
,
Zhang
,
A.
,
Zhou
,
X.
,
Webb
,
P.
,
He
,
W.
, and
Xia
,
X.
,
2012
, “
Thyroid Hormone Analogue Stimulates Keratinocyte Proliferation but Inhibits Cell Differentiation in Epidermis
,”
Int. J. Immunopathol. Pharmacol.
,
25
(
4
), pp.
859
869
. Available at: http://connection.ebscohost.com/c/articles/89166477/thyroid-hormone-analogue-stimulates-keratinocyte-proliferation-but-inhibits-cell-differentiation-epidermis
38.
Safer
,
J. D.
,
Crawford
,
T. M.
,
Fraser
,
L. M.
,
Hoa
,
M.
,
Ray
,
S.
,
Chen
,
T. C.
,
Persons
,
K.
, and
Holick
,
M. F.
,
2003
, “
Thyroid Hormone Action on Skin: Diverging Effects of Topical Versus Intraperitoneal Administration
,”
Thyroid
,
13
(
2
), pp.
159
165
.10.1089/105072503321319468
39.
Safer
,
J. D.
,
2013
, “
Thyroid Hormone and Wound Healing
,”
J. Thyroid Res.
,
2013
, p.
124538
.10.1155/2013/124538
40.
Elsabahy
,
M.
, and
Wooley
,
K. L.
,
2012
, “
Design of Polymeric Nanoparticles for Biomedical Delivery Applications
,”
Chem. Soc. Rev.
,
41
(
7
), pp.
2545
2561
.10.1039/c2cs15327k
41.
Santini
,
F.
,
Vitti
,
P.
,
Chiovato
,
L.
,
Ceccarini
,
G.
,
Macchia
,
M.
,
Montanelli
,
L.
,
Gatti
,
G.
,
Rosellini
,
V.
,
Mammoli
,
C.
,
Martino
,
E.
,
Chopra
,
I. J.
,
Safer
,
J. D.
,
Braverman
,
L. E.
, and
Pinchera
,
A.
,
2003
, “
Role for Inner Ring Deiodination Preventing Transcutaneous Passage of Thyroxine
,”
J. Clin. Endocrinol. Metab.
,
88
(
6
), pp.
2825
2830
.10.1210/jc.2002-021439
42.
Schoepe
,
S.
,
Vonk
,
R.
,
Schäcke
,
H.
,
Zollner
,
T. M.
,
Asadullah
,
K.
, and
Röse
,
L.
,
2011
, “
Shortened Treatment Duration of Glucocorticoid-Induced Skin Atrophy in Rats
,”
Exp.Dermatol.
,
20
(
10
), pp.
853
855
.10.1111/j.1600-0625.2011.01341.x
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