Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner.
Design and Fabrication of a Microfluidic Device for Synthesis of Chitosan Nanoparticles
Manuscript received November 25, 2013; final manuscript received December 6, 2013; published online January 29, 2014. Assoc. Editor: Sushanta K Mitra.
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Cetin, B., Asik, M. D., and Taze, S. (January 29, 2014). "Design and Fabrication of a Microfluidic Device for Synthesis of Chitosan Nanoparticles." ASME. J. Nanotechnol. Eng. Med. August 2013; 4(3): 031004. https://doi.org/10.1115/1.4026287
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