Despite the progress in tissue engineering, several challenges must be addressed for organ printing to become a reality. The most critical challenge is the integration of a vascular network, which is also a problem that the majority of tissue engineering technologies are facing. An embedded microfluidic channel network is probably the most promising solution to this problem. However, the available microfluidic channel fabrication technologies either have difficulty achieving a three-dimensional complex structure or are difficult to integrate within cell printing process in tandem. In this paper, a novel printable vessel-like microfluidic channel fabrication method is introduced that enables direct bioprinting of cellular microfluidic channels in form of hollow tubes. Alginate and chitosan hydrogels were used to fabricate microfluidic channels showing the versatility of the process. Geometric characterization was performed to understand effect of biomaterial and its flow rheology on geometric properties. Microfluidic channels were printed and embedded within bulk hydrogel to test their functionality through perfusion of cell type oxygenized media. Cell viability experiments were conducted and showed great promise of the microfluidic channels for development of vascular networks.
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Direct Bioprinting of Vessel-Like Tubular Microfluidic Channels Available to Purchase
Yahui Zhang,
Yahui Zhang
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
Search for other works by this author on:
Yin Yu,
Yin Yu
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Biomedical Engineering,
The University of Iowa,
Iowa City, IA 52242
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Biomedical Engineering,
The University of Iowa,
Iowa City, IA 52242
Search for other works by this author on:
Ibrahim T. Ozbolat
Ibrahim T. Ozbolat
1
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
e-mail: [email protected]
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
e-mail: [email protected]
1Corresponding author.
Search for other works by this author on:
Yahui Zhang
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
Yin Yu
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Biomedical Engineering,
The University of Iowa,
Iowa City, IA 52242
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Biomedical Engineering,
The University of Iowa,
Iowa City, IA 52242
Ibrahim T. Ozbolat
BioMfG Laboratory,
Center for Computer-Aided Design,
Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
e-mail: [email protected]
Center for Computer-Aided Design,
The University of Iowa
,Iowa City, IA 52242
;Department of Mechanical and Industrial Engineering,
The University of Iowa,
Iowa City, IA 52242
e-mail: [email protected]
1Corresponding author.
Manuscript received February 15, 2012; final manuscript received April 26, 2013; published online July 23, 2013. Assoc. Editor: Shaurya Prakash.
J. Nanotechnol. Eng. Med. May 2013, 4(2): 020902 (7 pages)
Published Online: July 23, 2013
Article history
Received:
February 15, 2013
Revision Received:
April 26, 2013
Citation
Zhang, Y., Yu, Y., and Ozbolat, I. T. (July 23, 2013). "Direct Bioprinting of Vessel-Like Tubular Microfluidic Channels." ASME. J. Nanotechnol. Eng. Med. May 2013; 4(2): 020902. https://doi.org/10.1115/1.4024398
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