A slump molding process was developed to place microchannel geometries in a soda-lime glass substrate for a lab-on-chip bioanalytical device. The process was developed to overcome the biological and chemical reactivity associated with current polymer lab-on-a-chip substrates, and as an alternative to using more expensive glass material. A high speed micro mill and UV laser micromachining center were used to fabricate the negative geometries in the graphite mold material that was used. The slumping process of the soda-lime glass was done using a glass kiln. Microchannel dimensions were in the mesa scale range of 50 μm width × 10 μm depth. The heating schedule for slump molding of the soda-lime glass to take its final shape to these dimensions was determined and documented. The functionality of the slumping process and resultant soda-lime glass device was validated through murine nerve tissue experiments conducted through the bioanalytical device that was developed. The research represented a novel use of slump molding, a process traditionally known for producing artistic works for: (a) embossing engineered microchannels and (b) reliably processing a soda-lime glass substrate, a material known to be difficult to work with due to its poor physical properties.

References

References
1.
Rodriguez
,
I.
,
Spicar-Mihalic
,
S.
,
Kuyper
,
C. L.
,
Fiorini
,
G. S.
, and
Chiu
,
D. T.
,
2003
, “
Rapid Prototyping of Glass Microchannels
,”
Anal. Chim. Acta
,
469
(
1–2
), pp.
205
215
.10.1016/S0003-2670(03)01000-6
2.
Sayah
,
A.
,
Thivolle
,
P. A.
, and
Prakesh
,
V. K.
,
2009
, “
Fabrication of Microfluidic Mixers With Varying Topography in Glass Using the Powder Blasting Process
,”
J. Micromech. Microeng.
,
19
(
8
), p. 085024.10.1088/0960-1317/19/8/085024
3.
Specialty Glass Products, Glass Types and Materials
,” http://www.sgpinc.com/materials.htm
4.
Thermo Scientific
, “
Material Properties Sheet- Microscope Glass Slides
,” http://www.thermoscientific.com/en/product/british-standard-microscope-slides.html
5.
Soda-Lime Glass
,” Encyclopædia Britannica Online, http://www.britannica.com/EBchecked/topic/551995/soda-lime-glass
6.
Li
,
X.
,
Abe
,
T.
, and
Esashi
,
M.
,
2001
, “
Deep Reactive Ion Etching of Pyrex Glass Using SF6 Plasma
,”
Sens. Actuators, A
,
87
(
3
), pp.
139
145
.10.1016/S0924-4247(00)00482-9
7.
Choi
,
W.
,
Lee
,
J.
,
Kim
,
W. B.
,
Min
,
B. K.
,
Kang
,
S.
, and
Lee
,
S. J.
,
2004
, “
Design and Fabrication of Tungsten Carbide Mould With Micropatterns Imprinted by Microlithography
,”
J. Micromech. Microeng.
,”
14
(
11
), pp.
1519
1525
.10.1088/0960-1317/14/11/012
8.
Iliescu
,
C.
,
Jing
,
J.
,
Tay
,
F. E. H.
,
Miao
,
J.
, and
Sun
,
T.
,
2005
, “
Characterization of Masking Layers for Deep Wet Etching of Glass in an Improved HF/HCl Solution
,”
Surf. Coat. Technol.
,
198
(
1–3
), pp.
314
318
.10.1016/j.surfcoat.2004.10.094
11.
Glass Fusing Made Easy
,” http://www.glass-fusing-made-easy.com
12.
MatWeb, Your Source for Materials Information
,” www.matweb.com
14.
Jacobs
,
J. A.
, and
Kilduff
,
T. F.
,
2004
,
Engineering Materials Technology: Structures, Processing, Properties, and Selection
,
5th ed.
,
Prentice Hall
,
Upper Saddle River, NJ
.
15.
Paragon TnF-66-3
,” http://www.paragonweb.com/TNF663.cfm
16.
Culler
,
R.
,
2010
,
Glass Art From the Kiln
,
Schiffer Publishing Ltd.
,
Atglen, PA
.
17.
Youn
,
S. W.
,
Takahashi
,
M.
,
Goto
,
H.
, and
Maeda
,
R.
,
2007
, “
Fabrication of Micro-Mold for Glass Embossing Using Focused Ion Beam Femto-Second laser, Eximer Laser and Dicing Techniques
,”
J. Mater. Process. Technol.
,
187/188
, pp.
326
330
.10.1016/j.jmatprotec.2006.11.120
18.
Takahashi
,
M.
,
Sugimoto
,
K.
, and
Maeda
,
R.
,
2005
, “
Nanoimprint of Glass Materials With Glassy Carbon Molds Fabricated by Focused-Ion-Beam Etching
,”
Jan. J. Appl. Phys.
,
44
(
7B
), pp.
5600
5605
.10.1143/JJAP.44.5600
19.
Hirai
,
Y.
,
Kanakugi
,
K.
,
Yamaguchi
,
T.
,
Yao
,
K.
,
Kitagawa
,
S.
, and
Tanaka
,
Y.
,
2003
, “
Fine Pattern Fabrication on Glass Surface by Imprint Lithography
,”
Microelectron. Eng.
,
67/68
, pp.
237
244
.10.1016/S0167-9317(03)00077-7
20.
Kuhnke
,
M.
,
Lippert
,
T.
,
Ortelli
,
E.
,
Scherer
,
G. G.
, and
Wokaun
,
A.
,
2004
, “
Microstructuring of Glassy Carbon: Comparison of Laser Machining and Reactive Ion Etching
,”
Thin Solid Films
,
453/454
, pp.
36
41
.10.1016/j.tsf.2003.11.156
You do not currently have access to this content.