A slump molding process was developed to place microchannel geometries in a soda-lime glass substrate for a lab-on-chip bioanalytical device. The process was developed to overcome the biological and chemical reactivity associated with current polymer lab-on-a-chip substrates, and as an alternative to using more expensive glass material. A high speed micro mill and UV laser micromachining center were used to fabricate the negative geometries in the graphite mold material that was used. The slumping process of the soda-lime glass was done using a glass kiln. Microchannel dimensions were in the mesa scale range of 50 μm width × 10 μm depth. The heating schedule for slump molding of the soda-lime glass to take its final shape to these dimensions was determined and documented. The functionality of the slumping process and resultant soda-lime glass device was validated through murine nerve tissue experiments conducted through the bioanalytical device that was developed. The research represented a novel use of slump molding, a process traditionally known for producing artistic works for: (a) embossing engineered microchannels and (b) reliably processing a soda-lime glass substrate, a material known to be difficult to work with due to its poor physical properties.
Slump Molding of Microchannel Arrays in Soda-Lime Glass for Bioanalytical Device Development
Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF MICRO- AND NANO-MANUFACTURING. Manuscript received January 29, 2014; final manuscript received August 28, 2014; published online September 26, 2014. Assoc. Editor: John P. Coulter.
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Billo, R. E., Wilson, P. A., Priest, J. W., Romero-Ortega, M., Brunskill, S. R., and Keens, D. (September 26, 2014). "Slump Molding of Microchannel Arrays in Soda-Lime Glass for Bioanalytical Device Development." ASME. J. Micro Nano-Manuf. December 2014; 2(4): 041006. https://doi.org/10.1115/1.4028487
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