Asthma is characterized by chronic airway inflammation, airway remodeling, and excessive constriction of the airway. Detailed investigation exploring inflammation and the role of immune cells has revealed a variety of possible mechanisms by which chronic inflammation drives asthma development. However, the underlying mechanisms of asthma pathogenesis still remain poorly understood. New evidence now suggests that mechanical stimuli that arise during bronchoconstriction may play a critical role in asthma development. In this article, we review the mechanical effect of bronchoconstriction and how these mechanical stresses contribute to airway remodeling independent of inflammation.
The Aftermath of Bronchoconstriction
Harvard T. H. Chan School of Public Health,
665 Huntington Avenue, 1-G07,
Boston, MA 02115
Manuscript received October 11, 2018; final manuscript received October 30, 2018; published online January 22, 2019. Assoc. Editor: Chun Seow.
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O'Sullivan, M. J., and Lan, B. (January 22, 2019). "The Aftermath of Bronchoconstriction." ASME. ASME J of Medical Diagnostics. February 2019; 2(1): 010803. https://doi.org/10.1115/1.4042318
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