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Keyword: balloon expansion
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Journal Articles
Niels Grabow, Carsten M. Bünger, Katrin Sternberg, Steffen Mews, Kathleen Schmohl, Klaus-Peter Schmitz
Article Type: Technical Briefs
J. Med. Devices. March 2007, 1(1): 84–88.
Published Online: August 10, 2006
... biomedical equipment casting poly(L-lactide) (PLLA) stent balloon expansion laser machining mechanical properties recoil collapse pressure degradation The potential of temporary, biodegradable intravascular stents has been advocated ever since permanent metallic stents were successfully...
Abstract
Background: Biodegradable polymeric stents represent a competitive approach to permanent and absorbable metallic stents for vascular applications. Despite major challenges resulting from the mechanical properties of polymeric biomaterials, these stent concepts gain their attraction from their intrinsic potential for controlled biodegradation and facile drug incorporation. This study demonstrates the mechanical properties of a novel balloon-expandable slotted tube stent from PLLA. Method of Approach: Polymeric balloon-expandable slotted tube stents (nominal dimensions: 6.0 × 25 mm ) were manufactured by laser machining of solution cast tubes ( I . D . = 2.8 mm , d = 270 ± 20 μ m ) from biodegradable (1) PLLA and (2) PLLA/PCL/TEC. The stents were tested in vitro for their mechanical properties: deployment, recoil, shortening, collapse, and creep behavior under a static load of 100 mm Hg . In vitro degradation was performed in Sørensen buffer solution at 37 ° C . After 0 ∕ 2 ∕ 4 ∕ 8 ∕ 12 ∕ 24 weeks the remaining collapse stability and molecular weight were assessed. Results: All stents could be deployed by balloon inflation to 8 bar at 1 bar ∕ min (PLLA) and 3 bar ∕ min (PLLA/PCL/TEC). Recoil, shortening, and collapse pressure were: 2.4 % ∕ 3.4 % ∕ 0.67 bar (PLLA), and 8.8 % ∕ 2.3 % ∕ 0.23 bar (PLLA/PCL/TEC). A static load of 100 mmHg induced pronounced creep processes in the PLLA/PCL/TEC stent. The PLLA stent remained patent and exhibited no creep propensity. During in vitro degradation an increase in collapse pressure was observed (maxima at 12 w : 1.3 bar (PLLA), 0.7 bar (PLLA/PCL/TEC)). At 24 weeks, molecular weight was decreased by 28% (PLLA), and 52% (PLLA/PCL/TEC). Conclusions: Stents fabricated from pure PLLA exhibited adequate mechanical properties. The slow permissible deployment rate, however, limits their potential application range and demands further development.