Previous studies have shown that many S-nitrosothiols (RSNOs) rapidly degrade, with half-lives from minutes to seconds in aqueous solution . The research presented in this paper presents data that the RSNO 1,3-benzenedinitrosothiol has been relatively stable for over 1 year. This RSNO still releases nitric oxide (NO) when subjected to ultraviolet light and has the same characteristic absorbance peak as a freshly made RSNO. Developing this stable RSNO potentially provides a venue for further investigation into using this NO donor to improve the biocompatibility of implanted optical sensors.
Toward the Development of Novel Nitric Oxide Donating Polymeric Materials to Improve the Biocompatibility of Implanted Devices
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Moore, E., and Frost, M. C. (August 11, 2010). "Toward the Development of Novel Nitric Oxide Donating Polymeric Materials to Improve the Biocompatibility of Implanted Devices." ASME. J. Med. Devices. June 2010; 4(2): 027532. https://doi.org/10.1115/1.3443738
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