The ElectroNanospray process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. A model drug delivery system consisting of a polymer matrix (arborescent polyisobutylene-polystyrene, or arbIBS) and either dexamethasone or sirolimus was studied by various characterization techniques. Modification of ElectroNanospray process parameters resulted in surface coatings with rich morphologies that are revealed by SEM, Atomic Force Microscopy (AFM) and Confocal Raman Microscopy were employed to monitor the drug release process in situ, through which the mechanism of the drug-eluting process may be proposed. A Confocal Raman microscope fitted with underwater objective was used to image arbIBS∕drug films incubated in phosphate-buffered saline over and at various film depths. Drug migrated from more concentrated areas into the surrounding polymer and toward the surface, beginning as early as after placing the sample in buffer and continuing throughout the period. High drug levels remained in the more concentrated areas at the end of incubation, suggesting the potential for prolonged release. SEM and AFM images taken from samples post incubation showed the appearance of nanoscale pores in diameter in areas corresponding in size and distribution to the Confocal Raman planar image areas of increased drug concentration. Confocal Raman microscopy offers a powerful new technique for demonstrating real-time drug release from therapeutic medical device coatings.
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Design Of Medical Devices Conference Abstracts
Real-Time Drug Release Imaging From Nanocomposite Drug and Polymer Coatings
Jinping Dong,
Jinping Dong
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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Greg Haugstad,
Greg Haugstad
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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Chris Frethem,
Chris Frethem
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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John Foley,
John Foley
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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Bob Hoerr,
Bob Hoerr
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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Mike Matuszewski,
Mike Matuszewski
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
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Judit Puskas
Judit Puskas
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Search for other works by this author on:
Jinping Dong
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Greg Haugstad
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Chris Frethem
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
John Foley
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Bob Hoerr
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Mike Matuszewski
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)
Judit Puskas
Characterization Facility (UMN),
Nanocopoeia Inc.
, Polymer Science (UAkron)J. Med. Devices. Jun 2008, 2(2): 027536 (1 pages)
Published Online: June 25, 2008
Article history
Published:
June 25, 2008
Citation
Dong, J., Haugstad, G., Frethem, C., Foley, J., Hoerr, B., Matuszewski, M., and Puskas, J. (June 25, 2008). "Real-Time Drug Release Imaging From Nanocomposite Drug and Polymer Coatings." ASME. J. Med. Devices. June 2008; 2(2): 027536. https://doi.org/10.1115/1.2927430
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