Sterilization is a vital component of the manufacturing process for any medical device. However, some sterilization techniques may alter device properties. While it is known that electron beam sterilization can change the mechanical properties of solid polymethylmethacrylate (PMMA) constructs, its effect on porous PMMA has not been explored. Therefore, porous PMMA space maintainer constructs designed for the treatment of craniofacial bone defects were sterilized at dosages of 30 kGy and 40 kGy. Electron beam sterilization was shown to increase the compressive properties of porous PMMA space maintainer devices.

References

References
1.
Goodger
,
N. M.
,
Wang
,
J.
,
Smagalski
,
G. W.
, and
Hepworth
,
B.
,
2005
, “
Methylmethacrylate as a Space Maintainer in Mandibular Reconstruction
,”
J. Oral. Maxillofac. Surg.
,
63
(
7
), pp.
1048
1051
.10.1016/j.joms.2005.03.024
2.
Kretlow
,
J. D.
,
Shi
,
M.
,
Young
,
S.
,
Spicer
,
P. P.
,
Demian
,
N.
,
Jansen.
,
J. A.
,
Wong
,
M. E.
,
Kasper
,
F. K.
, and
Mikos
,
A. G.
,
2010
, “
Evaluation of Soft Tissue Coverage Over Porous Polymethylmethacrylate Space Maintainers Within Nonhealing Alveolar Bone Defects
,”
Tissue Eng. Part C
,
16
(
6
), pp.
1427
1438
.10.1089/ten.tec.2010.0046
3.
Shi
,
M.
,
Kretlow
,
J. D.
,
Nguyen
,
A.
,
Young
,
S.
,
Baggett
,
L. S.
,
Wong
,
M. E.
,
Kasper
,
F. K.
, and
Mikos
,
A. G.
,
2010
, “
Antibiotic-Releasing Porous Polymethylmethacrylate Constructs for Osseous Space Maintenance and Infection Control
,”
Biomaterials
,
31
(
14
), pp.
4146
4156
.10.1016/j.biomaterials.2010.01.112
4.
Vaandrager
,
J. M.
,
van Mullem
,
P. J.
, and
de Wijn
,
J. R.
,
1983
, “
Porous Acrylic Cement for the Correction of Craniofacial Deformities and Repair of Defects, Animal Experimentation and Two Years of Clinical Application
,”
Biomaterials
,
4
(
2
), pp.
128
130
.10.1016/0142-9612(83)90053-4
5.
Spicer
,
P. P.
,
Shah
,
S. R.
,
Henslee
,
A. M.
,
Watson
,
B. W.
,
Kinard
,
L. A.
,
Kretlow
,
J. D.
,
Bevil
,
K.
,
Kattchee
,
K.
,
Bennett
,
G. N.
,
Demian
,
N.
,
Mende
,
K.
,
Murray
,
C. K.
,
Jansen
,
J. A.
,
Wong
,
M. E.
,
Mikos
,
A. G.
, and
Kasper
,
F. K.
,
2013
, “
Evaluation of Antibiotic Releasing Porous Polymethylmethacrylate Space Maintainers in an Infected Composite Tissue Defect Model
,”
Acta Biomater.
,
9
(
11
), pp.
8832
8839
.10.1016/j.actbio.2013.07.018
6.
Shi
,
M.
,
Kretlow
,
J. D.
,
Spicer
,
P. P.
,
Tabata
,
Y.
,
Demian
,
N.
,
Wong
,
M. E.
,
Kasper
,
F. K.
, and
Mikos
,
A. G.
,
2011
, “
Antibiotic-Releasing Porous Polymethylmethacrylate/Gelatin/Antibiotic Constructs for Craniofacial Tissue Engineering
,”
J. Controlled Release
,
152
(
1
), pp.
196
205
.10.1016/j.jconrel.2011.01.029
7.
Wang
,
L.
,
Yoon
,
D. M.
,
Spicer
,
P. P.
,
Henslee
,
A. M.
,
Scott
,
D. W.
,
Wong
,
M. E.
,
Kasper
,
F. K.
, and
Mikos
,
A. G.
,
2013
, “
Characterization of Porous Polymethylmethacrylate Space Maintainers for Craniofacial Reconstruction
,”
J. Biomed. Mater. Res. Part B
,
101
(
5
), pp.
813
825
.10.1002/jbm.b.32885
8.
Ouano
,
A. C.
,
1978
, “
A Study on the Dissolution Rate of Irradiated Poly (Methyl Methacrylate)
,”
Polym. Eng. Sci.
,
18
(
4
), pp.
306
313
.10.1002/pen.760180412
9.
Lee
,
E. H.
,
Rao
,
G. R.
, and
Mansur
,
L. K.
,
1999
, “
LET Effect on Cross-Linking and Scission Mechanisms of PMMA During Irradiation
,”
Radiat. Phys. Chem.
,
55
(
3
), pp.
293
305
.10.1016/S0969-806X(99)00184-X
10.
Cho
,
S. O.
, and
Jun
,
H. Y.
,
2005
, “
Surface Hardening of Poly (Methyl Methacrylate) by Electron Irradiation
,”
Nucl. Instrum. Methods Phys. Res., Sect. B
,
237
(
3
), pp.
525
532
.10.1016/j.nimb.2005.03.007
11.
Allen
,
J. T.
,
Calhoun
,
R.
,
Helm
,
J.
,
Kruger
,
S.
,
Lee
,
C.
,
Mendonsa
,
R.
,
Meyer
,
S.
,
Pageau
,
G.
,
Shaffer
,
H.
,
Whitham
,
K.
,
Williams
,
C. B.
, and
Farrell
,
J. P.
,
1995
, “
A Fully Integrated 10 MeV Electron Beam Sterilization System
,”
Radiat. Phys. Chem.
,
46
(
4
), pp.
457
460
.10.1016/0969-806X(95)00193-2
12.
Benson
,
R. S.
,
2002
, “
Use of Radiation in Biomaterials Science
,”
Nucl. Instrum. Methods Phys. Res. Sect. B
,
191
(
1
), pp.
752
757
.10.1016/S0168-583X(02)00647-X
13.
Rittel
,
D.
, and
Brill
,
A.
,
2008
, “
Dynamic Flow and Failure of Confined Polymethylmethacrylate
,”
J. Mech. Phys. Solids
,
56
(
4
), pp.
1401
1416
.10.1016/j.jmps.2007.09.003
You do not currently have access to this content.