Colorectal cancer is the third most common cancer in the world. Surgery is the main treatment in eight out of ten people with bowel cancer. Though colectomy can remove tumour, the complications aroused by suture and surgical stapling, such as inflammation, bleeding, and leakage of anastomotic site [1] are still problems. The feasibility of radiofrequency (RF)-induced intestinal anastomoses is demonstrated recent years [2–5]. The technique makes anastomotic site continuous and does not introduce foreign material, thus improves the quality of patients' lives by reducing bleeding and inflation.

To date, the reported studies on RF thermofusion technology have addressed several aspects, including effects caused by changing energy and compression pressures (CP) [6–8]; comparative studies with mechanical anastomoses[2,4,5]; histopathological studies including thermal damage [9,10]; and molecular biological studies of altered function...

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