Botox treatments are among widely used treatment options. Cosmetic surgeons are generally asked to carry out the operation for individuals seeking to alleviate wrinkles as well as fine lines on their looks. Botox is short name for botulinum toxin A with median lethal dose of 40–56 ng [1]. The cosmetic effect of Botox was introduced by Clark in 1989 [2]. It is based on the fact that the botulinum toxin blocks the nerve signals that instruct the muscles to contract [3]. Therefore, the function of the Botox is to disable the muscle contraction by stopping the acetylcholine from releasing and freezing the muscles so that they tend not to wrinkle during recurring activity [3]. Botox treatments cannot eliminate all indications of aging as well as other environmental effects on the skin. Only motion wrinkles might be minimized...

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