A common theme in the design of intrasaccular devices for cerebral aneurysm therapy is to establish an initial complete occlusion by maximizing the endosaccular density of occlusion material. In the event of a technically successful treatment, it is anticipated that a strong thrombus complex will form around the endosaccular device implants and remodel into a collagenous plug/scar to redirect the flow away from the lesion. However, the effect of cyclic hemodynamic loads on endosaccular thrombus complex and the ability of the composite occlusion matrix to maintain structural integrity of the treated aneurysm wall have been largely ignored in the development of new devices.

Our hypothesis is that the stiffness of the endosaccular thrombus complex and the morphology of occluded state play a critical role in unloading the aneurysm wall from transmural pressures and determining the effectiveness of intrasaccular therapy. To test this hypothesis, we present...

References

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