Current minimally invasive laparoscopic tissue–harvesting techniques for pathological purposes involve taking multiple imprecise and inaccurate biopsies, usually using a laparoscopic forceps or other assistive devices. Potential hazards, e.g., cancer spread when dealing with tumorous tissue, call for a more reliable alternative in the form of a single laparoscopic instrument capable of repeatedly taking a precise biopsy at a desired location. Therefore, the aim of this project was to design a disposable laparoscopic instrument tip, incorporating a centrally positioned glass fiber for tissue diagnostics; a cutting device for fast, accurate, and reliable biopsy of a precisely defined volume; and a container suitable for sample storage. Inspired by the sea urchin's chewing organ, Aristotle's lantern, and its capability of rapid and simultaneous tissue incision and enclosure by axial translation, we designed a crown-shaped collapsible cutter operating on a similar basis. Based on a series of in vitro experiments indicating that tissue deformation decreases with increasing penetration speed leading to a more precise biopsy, we decided on the cutter's forward propulsion via a spring. Apart from the embedded spring-loaded cutter, the biopsy harvester comprises a smart mechanism for cutter preloading, locking, and actuation, as well as a sample container. A real-sized biopsy harvester prototype was developed and tested in a universal tensile testing machine at TU Delft. In terms of mechanical functionality, the preloading, locking, and actuation mechanism as well as the cutter's rapid incising and collapsing capabilities proved to work successfully in vitro. Further division of the tip into a permanent and a disposable segment will enable taking of multiple biopsies, mutually separated in individual containers. We believe the envisioned laparoscopic optomechanical biopsy device will be a solution ameliorating time-demanding, inaccurate, and potentially unsafe laparoscopic biopsy procedures.
Bioinspired Spring-Loaded Biopsy Harvester—Experimental Prototype Design and Feasibility Tests
Manuscript received June 13, 2013; final manuscript received December 16, 2013; published online January 20, 2014. Assoc. Editor: Rosaire Mongrain.
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
- Search Site
Jelínek, F., Smit, G., and Breedveld, P. (January 20, 2014). "Bioinspired Spring-Loaded Biopsy Harvester—Experimental Prototype Design and Feasibility Tests." ASME. J. Med. Devices. March 2014; 8(1): 015002. https://doi.org/10.1115/1.4026449
Download citation file:
- Ris (Zotero)
- Reference Manager