Modeling and simulation of medical devices are typically established to identify parameter dependencies within the system of interest. Most devices are multiphysics problems considering solid and fluid mechanics, and electromagnetic mechanisms bridging time and length scales. Typically, the geometries of interest are described by complex morphologies of biological components. These factors all contribute to significant complexity of the developed numerical models. Access to imaging modalities capable of providing the geometrical information of relevance is central in the establishment and verification of numerical analysis. Here, data from image-based models obtained with MRI and μCT to risk access patients prone to realizing stroke, and to evaluate drug eluding scaffolds is presented.

References

1.
Kock
,
S. A.
, Nygaard, J. V., Eldrup, N., Fründ, E.-T., Klærke, A., Paaske, W. P., Falk, E., and Kim, W. Y.,
2008
, “
Mechanical Stresses in Carotid Plaques Uusing MRI-Based Fluid-Structure Interaction Models
,”
J. Biomech.
,
41
(8),
1651
1658
.10.1016/j.jbiomech.2008.03.019
2.
Thrysoe
,
S. A.
, Oikawa, M., Yuan, C., Eldrup, N., Klærke, A., Paaske, W. P., Falk, E., Kim, W. Y., and Nygaard, J. V.,
2010
, “
Longitudinal Distribution of Mechanical Stresses in Carotid Plaques of Symptomatic Patients
,”
Stroke
,
41
,
1041
1043
.10.1161/STROKEAHA.109.571588
3.
Thrysøe
,
S. A.
, Stegmann, A. F., Eldrup, N., Klærke, A., Paaske, W., Kim, W. Y., and Nygaard, J. V.,
2012
, “
The Effect of Carotid Plaque Morphology on Longitudinal Fibrous Cap Stress Levels
,”
World J. Mech.
,
2
,
216
223
.10.4236/wjm.2012.24026
4.
Andersen
,
M. Ø.
, Nygaard, J. V., Burns, J. S., Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M., and Kjems, J.,
2010
, “
siRNA Nanoparticle Functionalization of Nanostructured Scaffolds Enables Controlled Multilineage Differentiation of Stem Cells
,”
Molecular Therapy: J. Ame. Soc. Gene Therapy
,
18
(11), pp. 2018–2027.10.1038/mt.2010.166
5.
Nygaard
,
J. V.
, Andersen, M. Ø., Howard, K. A., Foss, M., Bünger, C., Kjems, J., and Besenbacher, F.,
2008
, “
Investigation of Particle-Functionalized Tissue Engineering Scaffolds Using X-Ray Tomographic Microscopy
,”
Biotechnology and Bioengineering
,
100
(4),
820
829
.10.1002/bit.21796
6.
Wittenborn
,
T.
, Nielsen, T., Nygaard, J. V., Larsen, E. K. U., Thim, T., Rydtoft, L. M., Vorup-Jensen, T., Kjems, J., Nielsen, N. C., Horsman, M. R., and Falk, E.,
2012
, “
Ultrahigh-Field DCE-MRI of Angiogenesis in a Novel Angiogenesis Mouse Model
,”
J. Magnetic Resonance Imaging
,
35
(3), pp. 703–710.10.1002/jmri.22855
You do not currently have access to this content.