Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability in the United States, accounting for 1 out of every 18 deaths [1]. Each year 795,000 people experience a new stroke. Studies show that the ability to rapidly induce localized mild hypothermia has proven benefits in reduction of tissue death from an ischemic stroke, which account for 87% of strokes [1]. A mild reduction of 2–5 °C in tissue temperature has shown reduced tissue infarct size, increased tissue recovery, and positive neurological effects [2,3]. This paper seeks to validate a thermal fluids finite element (TFFE) model of blood temperatures in a canine vasculature using in-vitro experiments, following a thrombectomy procedure. The model will allow for future work in predicting deep brain tissue hypothermia in human models.

Therapeutic hypothermia (TH) reduces a...

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