Visualizing and characterizing vascular structures is important for many areas of health care, from accessing difficult veins and arteries for laboratory testing, to diagnosis and treatment of cardiovascular disease. Photoacoustic (PA) imaging, one of the fastest growing fields of biomedical imaging, is well suited for this task. PA imaging is based on the photoacoustic effect, which starts with a pulsed laser source incident on biological tissue. If the wavelength of the source matches an absorption wavelength of a chromophore within the tissue, a portion of the pulse energy is absorbed by the chromophore and converted into heat. A subsequent increase in temperature, followed by an increase in pressure occurs. Acoustic waves are emitted when this pressure relaxes, which can be detected at the surface of the tissue. PA imaging is considered absorption based, therefore spectroscopic information can be extracted. Yet, unlike purely optical imaging techniques,...

References

References
1.
Guo
,
Z.
,
Hu
,
S.
,
and Wang, L. H. V.
,
2010
, “
Calibration-Free Absolute Quantification of Optical Absorption Coefficients Using Acoustic Spectra in 3D Photoacoustic Microscopy of Biological Tissue
,”
Opt. Lett.
,
35
(
12
), pp.
2067
2069
.
2.
Allen
,
T. J.
,
Hall
,
A.
,
Dhillon
,
A. P.
,
Owen
,
J. S.
, and
Beard
,
P. C.
,
2011
, “
Spectroscopic Photoacoustic Imaging of Lipid-Rich Plaques in the Human Aorta in the 740 to 1400 nm Wavelength Range
,”
J. Biomed. Opt.
,
17
(
6
), p.
061209
.10.1117/1.JBO.17.6.061209
3.
Balogun
,
O.
, and
Murray
,
T. W.
,
2011
, “
Frequency Domain Photoacoustics Using Intensity-Modulated Laser Sources
,”
Nondestructive Testing and Evaluation
,
26
(
3−4),
pp.
335
351
.10.1080/10589759.2011.573554
4.
Rousseau
,
G.
,
Gauthier
,
B.
,
Blouin
,
A.
,
Monchalin
,
J. P.
, “
Non-Contact Biomedical Photoacoustic and Ultrasound Imaging
,”
J. Biomed. Opt.
,
17
(
6
), p.
061217
.10.1117/1.JBO.17.6.061217
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