Automating image-guided therapy and registering a medical image to a patient require knowledge of the locations of both the medical image source (e.g., ultrasound) and the surgical tool with respect to a global coordinate system that is known relative to the patient. Also, sturdiness of the medical instrumentations is essential. A novel compact stabilizer-tracker integrated assembly is designed to serve as a holder that can be used to support, manipulate in six degrees-of-freedom, and firmly lock-in-place ultrasound imaging probes and other instruments for use in image-guided surgery as well as to provide the position and orientation of the probe in 3D space with respect to a known reference origin. The stabilizer’s configuration allows a clinician to easily manipulate an ultrasound probe in 3D space, and demonstrate improved sturdiness when locked. A reliable validation technique using forward kinematics was used to evaluate the performance of the holder. Performance tests show that the tracker assembly can acquire the position and orientation of the ultrasound probe with an average displacement accuracy of $0.66mm$ and roll, pitch, and yaw angular accuracies of $0.24deg$, $0.38deg$, and $0.19deg$, respectively. The improved sturdiness demonstrated by the compact-sized stabilizer and the high accuracy of the tracking mechanism make the integrated holder mechanism well suited for use in image-guided robot-assisted brachytherapy. It is anticipated that this will lead to improvement in accuracy and clinical outcomes for the procedure. The novel tracker can also be used to acquire the positions and orientations of other passive mechanisms of complex designs.

2.
Townsend
,
M.
,
Beauchamp
,
R.
,
Evers
,
B.
, and
Matox
,
K.
, 2001,
Sabiston Text Book of Surgery
,
16th ed.
,
Saunders
,
, pp.
1673
1681
.
3.
Ng
,
W. S.
,
Chung
,
V. R.
,
Vasan
,
S.
, and
Lim
,
P.
, 1996, “
Robotic Radiation Seed Implantation for Prostatic Cancer
,”
Proceedings of the 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
,
Amsterdam
, Vol.
1
, pp.
231
233
.
4.
Phee
,
L.
,
Xiao
,
D.
,
Yuen
,
J.
,
Chan
,
C. F.
,
Ho
,
H.
,
Thng
,
C. H.
,
Cheng
,
C.
, and
Ng
,
W. S.
, 2005, “
Ultrasound Guided Robotic System for Transperineal Biopsy of the Prostate
,”
Proceedings of the IEEE International Conference on Robotics and Automation
,
Barcelona
, pp.
1315
1320
.
5.
Wei
,
Z.
,
Wan
,
G.
,
Gardi
,
L.
,
Mills
,
G.
,
Downey
,
D.
, and
Fenster
,
A.
, 2004, “
Robot-Assisted 3D-TRUS Guided Prostate Brachytherapy: System Integration and Validation
,”
Med. Phys.
0094-2405,
31
(
3
), pp.
539
548
.
6.
Bassan
,
H.
,
Patel
,
R. V.
, and
Moallem
,
M.
, 2007, “
A Novel Manipulator for 3D Ultrasound Guided Percutaneous Needle Insertion
,”
IEEE International Conference on Robotics and Automation
,
Roma
, pp.
617
622
.
7.
,
J.
,
Stoianovici
,
D.
,
Chen
,
R. N.
,
Moore
,
R. G.
, and
Kavoussi
,
L. R.
, 1998, “
Stereotactic Mechanical Percutaneous Renal Access
,”
J. Endourol
0892-7790,
12
(
2
), pp.
121
126
.
8.
Stoianovici
,
D.
,
,
J. A.
,
Whitcomb
,
L. L.
,
Taylor
,
R. H.
, and
Kavoussi
,
L. R.
, 1998, “
A Robotic System for Precise Percutaneous Needle Insertion
,”
13th Annual Meeting of the Society for Urology and Engineering
,
San Diego, CA
.
9.
Stoianovici
,
D.
, 2001, “
URobotics—Urology Robotics at Johns Hopkins
,”
Comput. Aided Surg.
1092-9088,
6
(
6
), pp.
360
369
.
10.
Whitemore
III,
W.
,
Barzell
,
W.
, and
Wilson
,
R.
, 1999, “
Omni-Directional Precision Instrument Platform
,” U.S. Patent No. 5,961,527.
11.
Ellard
,
T.
, and
Knudsen
,
S.
, 2001, “
Stabilizer Assembly for Stepper Apparatus and Ultrasound Probe
,” U.S. Patent No. 6,179,262.
12.
Ellard
,
T.
, 1999, “
Stepper Apparatus for Use in the Imaging∕Treatment of Internal Organs Using an Ultrasound Probe
,” U.S. Patent No. 5,871,448.
13.
Whitemore
III,
W.
,
Barzell
,
W.
, and
Wilson
,
R.
, 1999, “
Ultrasound Probe Support and Stepping Device
,” U.S. Patent No. 5,931,786.
14.
Tong
,
S.
,
Downey
,
D.
,
Cardinal
,
H.
, and
Fenster
,
A.
, 1996, “
A Three-Dimensional Ultrasound Prostate Imaging System
,”
Ultrasound Med. Biol.
0301-5629,
22
(
6
), pp.
735
746
.
15.
Burdette
,
E.
, and
Komandina
,
B.
, 2003, “
Radiation Therapy and Real Time Imaging of a Patient Treatment Region
,” U.S. Patent No. 6,512,942.
16.
Nelson
,
T.
, and
Pretorius
,
D.
, 1998, “
Three-Dimensional Ultrasound Imaging
,”
Ultrasound Med. Biol.
0301-5629,
24
, pp.
1243
70
.
17.
Craig
,
J. J.
, 2005,
Introduction to Robotics: Mechanics and Control
,
3rd ed.
,
Pearson Education
,
.
18.
Yousef
,
B.
,
Patel
,
R. V.
, and
Moallem
,
M.
, 2006, “
Macro-Robot Manipulator for Medical Applications
,”
IEEE International Conference on Systems, Man and Cybernetics
, Taipei, Taiwan, pp.
530
535
.
19.
Yousef
,
B.
, 2007, “
Design of a Robot Manipulator and an Ultrasound Probe Holder for Medical Applications
,” Ph.D. thesis, The University of Western Ontario, London, Ontario, Canada.
20.
Yousef
,
B.
,
Patel
,
R. V.
, and
Moallem
,
M.
, 2007, “
An Ultrasound Probe Holder for Image-Guided Robot-Assisted Prostate Brachytherapy
,”
IEEE International Conference on Robotics and Automation
,
Roma
, pp.
232
237
.