Currently available motion-preserving orthopedic implants offer many advantages but have several limitations to their use, including short device lifetime, high part count, loss of natural kinematics, and wear-induced osteolysis and implant loosening. Compliant mechanisms have been used to address some of these problems as they offer several potential advantages - namely, wear reduction, reduced part count, and the ability to achieve complex, patient-specific motion profiles. This article provides a systematic review of compliant mechanisms as orthopedic implants. Based on the PRISMA guidelines for an efficient review, this work identified fourteen implantable orthopedic devices that seek to restore anatomical motion by utilizing mechanical compliance. From reviewing these implants and their results, advantages and consequences for each are summarized. Trends were also identified in how these devices are capable of mitigating common challenges found in orthopedic design. Design considerations for the development of future compliant orthopedic implants are proposed and discussed.