Abstract

Neuropathy is a nerve-damaging disease that causes those affected to lose feeling in their otherwise functional limbs. It can cause permanent numbing to the peripheral limb of a patient such as a hand or foot. In this report, we present a real-time visualization aid for grasp realization that can be used by patients experiencing numbness of the limb. This wearable electronic device was developed on an open-source microcontroller-based platform. This is a very simple and inexpensive solution. It is referred to as the NeuroGlove, and it provides patients with a visual light scale to allow them to understand the strength of the grasp that they have on any object. A soft tactile sensor was additively manufactured by utilizing a multimaterial direct-print system. The sensor consists of an ionic liquid (IL)-based pressure-sensitive membrane, stretchable electrodes, and insulation membranes. The printed flexible polymeric sensor was evaluated under varying forces. Next, the fabricated sensor was integrated with a microcontroller board where it was programmed to respond in a light scale according to the applied force on the sensor. Finally, the sensor-microcontroller system was installed on a glove to demonstrate a wearable visual aid for neuropathy patients. Additive manufacturing offers the ability for customization in a design, material, and geometry that could potentially lead to printing sensors on prosthetic or robotic hands.

References

1.
Vinik
,
A. I.
,
Nevoret
,
M.-L.
,
Casellini
,
C.
, and
Parson
,
H.
,
2013
, “
Diabetic Neuropathy
,”
Endocrinol. Metab. Clin. North Am.
,
42
(
4
), pp.
747
787
.10.1016/j.ecl.2013.06.001
2.
Organization
,
W. H.
,
2016
, “
World Health Statistics 2016: Monitoring Health for the SDGs Sustainable Development Goals
,”
World Health Organization
, Geneva, Switzerland.https://apps.who.int/iris/handle/10665/206498
3.
Martyn
,
C. N.
, and
Hughes
,
R. A.
,
1997
, “
Epidemiology of Peripheral Neuropathy
,”
J. Neurol. Neurosurg. Psychiatry
,
62
(
4
), pp.
310
318
.10.1136/jnnp.62.4.310
4.
Anastasi
,
J. K.
,
Capili
,
B.
, and
Chang
,
M.
,
2013
, “
HIV Peripheral Neuropathy and Foot Care Management: A Review of Assessment and Relevant Guidelines
,”
Am. J. Nurs.
,
113
(
12
), pp.
34
40
.10.1097/01.NAJ.0000438867.67777.69
5.
Quasthoff
,
S.
, and
Hartung
,
H. P.
,
2002
, “
Chemotherapy-Induced Peripheral Neuropathy
,”
J. Neurol.
,
249
(
1
), pp.
9
17
.10.1007/PL00007853
6.
Pop-Busui
,
R.
,
Boulton
,
A. J. M.
,
Feldman
,
E. L.
,
Bril
,
V.
,
Freeman
,
R.
,
Malik
,
R. A.
,
Sosenko
,
J. M.
, and
Ziegler
,
D.
,
2017
, “
Diabetic Neuropathy: A Position Statement by the American Diabetes Association
,”
Diabetes Care
,
40
(
1
), pp.
136
154
.10.2337/dc16-2042
7.
Llewelyn
,
J. G.
,
2003
, “
The Diabetic Neuropathies: Types, Diagnosis and Management
,”
J. Neurol. Neurosurg. Psychiatry
,
74
(
Suppl. 2
), pp.
ii15
ii19
.10.1136/jnnp.74.suppl_2.ii15
8.
Izenberg
,
A.
,
Perkins
,
B. A.
, and
Bril
,
V.
,
2015
, “
Diabetic Neuropathies
,”
Semin. Neurol.
,
35
(
4
), pp.
424
430
.10.1055/s-0035-1558972
9.
Zhou
,
N.
,
Liu
,
T.
,
Wen
,
B.
,
Gong
,
C.
,
Wei
,
G.
, and
Su
,
Z.
,
2020
, “
Recent Advances in the Construction of Flexible Sensors for Biomedical Applications
,”
Biotechnol. J.
,
15
(
12
), p.
2000094
.10.1002/biot.202000094
10.
Kenry
,
Yeo
,
J. C.
, and
Lim
,
C. T.
,
2016
, “
Emerging Flexible and Wearable Physical Sensing Platforms for Healthcare and Biomedical Applications
,”
Microsyst. Nanoeng.
,
2
(
1
), pp.
1
19
.https://doi.org/10.1038/micronano.2016.43
11.
Emon
,
M. O. F.
, and
Choi
,
J.-W.
,
2018
, “
A Preliminary Study on 3D Printed Smart Insoles With Stretchable Piezoresistive Sensors for Plantar Pressure Monitoring
,”
ASME
Paper No. IMECE2017-71817.10.1115/IMECE2017-71817
12.
Lee
,
J.
,
Emon
,
M. O. F.
,
Vatani
,
M.
, and
Choi
,
J.-W.
,
2017
, “
Effect of Degree of Crosslinking and Polymerization of 3D Printable Polymer/Ionic Liquid Composites on Performance of Stretchable Piezoresistive Sensors
,”
Smart Mater. Struct.
,
26
(
3
), p.
035043
.10.1088/1361-665X/aa5c70
13.
Emon
,
M. O. F.
,
Lee
,
J.
,
Choi
,
U. H.
,
Kim
,
D.
,
Lee
,
K.
, and
Choi
,
J.
,
2019
, “
Characterization of a Soft Pressure Sensor on the Basis of Ionic Liquid Concentration and Thickness of the Piezoresistive Layer
,”
IEEE Sens. J.
,
19
(
15
), pp.
6076
6084
.10.1109/JSEN.2019.2911859
14.
Marsh
,
K. N.
,
Boxall
,
J. A.
, and
Lichtenthaler
,
R.
,
2004
, “
Room Temperature Ionic Liquids and Their Mixtures—A Review
,”
Fluid Phase Equilib.
,
219
(
1
), pp.
93
98
.10.1016/j.fluid.2004.02.003
15.
Ohno
,
H.
,
2007
, “
Design of Ion Conductive Polymers Based on Ionic Liquids
,”
Macromol. Symp.
,
249–250
(
1
), pp.
551
556
.10.1002/masy.200750435
16.
Hwang
,
S.
, and
Jeong
,
S.-H.
,
2016
, “
Stretchable Carbon Nanotube Conductors and Their Applications
,”
Korean J. Chem. Eng.
,
33
(
10
), pp.
2771
2787
.10.1007/s11814-016-0130-6
17.
Liu
,
X.-M.
,
Huang
,
Z. D.
,
Oh
,
S. W.
,
Zhang
,
B.
,
Ma
,
P.-C.
,
Yuen
,
M. M. F.
, and
Kim
,
J.-K.
,
2012
, “
Carbon Nanotube (CNT)-Based Composites as Electrode Material for Rechargeable Li-Ion Batteries: A Review
,”
Compos. Sci. Technol.
,
72
(
2
), pp.
121
144
.10.1016/j.compscitech.2011.11.019
18.
Emon
,
M. O. F.
, and
Choi
,
J.-W.
,
2017
, “
Flexible Piezoresistive Sensors Embedded in 3D Printed Tires
,”
Sensors
,
17
(
3
), p.
656
.10.3390/s17030656
19.
Ngo
,
T. D.
,
Kashani
,
A.
,
Imbalzano
,
G.
,
Nguyen
,
K. T. Q.
, and
Hui
,
D.
,
2018
, “
Additive Manufacturing (3D Printing): A Review of Materials, Methods, Applications and Challenges
,”
Compos. Part B Eng.
,
143
, pp.
172
196
.10.1016/j.compositesb.2018.02.012
20.
Murr
,
L. E.
,
2016
, “
Frontiers of 3D Printing/Additive Manufacturing: From Human Organs to Aircraft Fabrication†
,”
J. Mater. Sci. Technol.
,
32
(
10
), pp.
987
995
.10.1016/j.jmst.2016.08.011
21.
Kim
,
M.
,
Philip
,
D. G.
,
Emon
,
M. O. F.
, and
Choi
,
J.-W.
,
2021
, “
Effects of Hardness on the Sensitivity and Load Capacity of 3D Printed Sensors
,”
Int. J. Precis. Eng. Manuf.
,
22
(
3
), pp.
483
494
.10.1007/s12541-020-00468-9
22.
Bhatt
,
P. M.
,
Malhan
,
R. K.
,
Shembekar
,
A. V.
,
Yoon
,
Y. J.
, and
Gupta
,
S. K.
,
2020
, “
Expanding Capabilities of Additive Manufacturing Through Use of Robotics Technologies: A Survey
,”
Addit. Manuf.
,
31
, p.
100933
.10.1016/j.addma.2019.100933
23.
Lee
,
J.
,
Lu
,
Y.
,
Kashyap
,
S.
,
Alarmdari
,
A.
,
Emon
,
M. O. F.
, and
Choi
,
J.-W.
,
2018
, “
Liquid Bridge Microstereolithography
,”
Addit. Manuf.
,
21
, pp.
76
83
.10.1016/j.addma.2018.02.012
24.
Meteyer
,
S.
,
Xu
,
X.
,
Perry
,
N.
, and
Zhao
,
Y. F.
,
2014
, “
Energy and Material Flow Analysis of Binder-Jetting Additive Manufacturing Processes
,”
Procedia CIRP
,
15
, pp.
19
25
.10.1016/j.procir.2014.06.030
25.
Weng
,
Z.
,
Wang
,
J.
,
Senthil
,
T.
, and
Wu
,
L.
,
2016
, “
Mechanical and Thermal Properties of ABS/Montmorillonite Nanocomposites for Fused Deposition Modeling 3D Printing
,”
Mater. Des.
,
102
, pp.
276
283
.10.1016/j.matdes.2016.04.045
26.
Shirazi
,
S. F. S.
,
Gharehkhani
,
S.
,
Mehrali
,
M.
,
Yarmand
,
H.
,
Metselaar
,
H. S. C.
,
Kadri
,
N. A.
, and
Osman
,
N. A. A.
,
2015
, “
A Review on Powder-Based Additive Manufacturing for Tissue Engineering: Selective Laser Sintering and Inkjet 3D Printing
,”
Sci. Technol. Adv. Mater.
,
16
(
3
), p.
033502
.10.1088/1468-6996/16/3/033502
27.
Reguera
,
P.
,
García
,
D.
,
Domínguez
,
M.
,
Prada
,
M. A.
, and
Alonso
,
S.
,
2015
, “
A Low-Cost Open Source Hardware in Control Education. CASE Study: Arduino-Feedback MS-150
,”
IFAC-PaperOnLine
,
48
(
29
), pp.
117
122
.10.1016/j.ifacol.2015.11.223
28.
Liao
,
L.-D.
,
Wang
,
Y.
,
Tsao
,
Y.-C.
,
Wang
,
I.-J.
,
Jhang
,
D.-F.
,
Chuang
,
C.-C.
, and
Chen
,
S.-F.
,
2020
, “
Design and Implementation of a Multifunction Wearable Device to Monitor Sleep Physiological Signals
,”
Micromachines
,
11
(
7
), p.
672
.10.3390/mi11070672
29.
El Hammoumi
,
A.
,
Motahhir
,
S.
,
Chalh
,
A.
,
El Ghzizal
,
A.
, and
Derouich
,
A.
,
2018
, “
Low-Cost Virtual Instrumentation of PV Panel Characteristics Using Excel and Arduino in Comparison With Traditional Instrumentation
,”
Renewables
,
5
(
1
), p.
3
.10.1186/s40807-018-0049-0
30.
Kim
,
R.-H.
, and
Cho
,
G.
,
2013
, “
Effectiveness of the Smart Healthcare Glove System for Elderly Persons With Hypertension
,”
Hum. Factors Ergon. Manuf. Serv. Ind.
,
23
(
3
), pp.
198
212
.10.1002/hfm.20361
31.
Sundaram
,
S.
,
Kellnhofer
,
P.
,
Li
,
Y.
,
Zhu
,
J.-Y.
,
Torralba
,
A.
, and
Matusik
,
W.
,
2019
, “
Learning the Signatures of the Human Grasp Using a Scalable Tactile Glove
,”
Nature
,
569
(
7758
), pp.
698
702
.10.1038/s41586-019-1234-z
32.
Shin
,
J.-H.
,
Kim
,
M.-Y.
,
Lee
,
J.-Y.
,
Jeon
,
Y.-J.
,
Kim
,
S.
,
Lee
,
S.
,
Seo
,
B.
, and
Choi
,
Y.
,
2016
, “
Effects of Virtual Reality-Based Rehabilitation on Distal Upper Extremity Function and Health-Related Quality of Life: A Single-Blinded, Randomized Controlled Trial
,”
J. Neuroeng. Rehabil.
,
13
(
1
), p.
17
.10.1186/s12984-016-0125-x
33.
Emon
,
M. O. F.
,
Alkadi
,
F.
,
Philip
,
D. G.
,
Kim
,
D.-H.
,
Lee
,
K.-C.
, and
Choi
,
J.-W.
,
2019
, “
Multi-Material 3D Printing of a Soft Pressure Sensor
,”
Addit. Manuf.
,
28
, pp.
629
638
.10.1016/j.addma.2019.06.001
34.
Tschoegl
,
N. W.
,
1997
, “
Time Dependence in Material Properties: An Overview
,”
Mech. Time-Depend. Mater.
,
1
(
1
), pp.
3
31
.10.1023/A:1009748023394
35.
Qiu
,
L.
,
Coskun
,
M. B.
,
Tang
,
Y.
,
Liu
,
J. Z.
,
Alan
,
T.
,
Ding
,
J.
,
Truong
,
V.-T.
, and
Li
,
D.
,
2016
, “
Ultrafast Dynamic Piezoresistive Response of Graphene-Based Cellular Elastomers
,”
Adv. Mater.
,
28
(
1
), pp.
194
200
.10.1002/adma.201503957
You do not currently have access to this content.