This work presents the design of an articulate neuroendoscopic instrument (ANI), a handheld tool for use in minimally invasive neurosurgery. The instrument consists of a handle and a steerable tube-shaft with a distal end-effector. The design aims to increase the reach of surgeons operating through narrow channels within the center of the brain when approaching multiple targets from a single incision point. The steerable tube-shaft consists of a 1.6- mm notch-tube compliant joint mechanism augmented with contact-aids modeled after a gear geometry. The contact-aid geometry aims to address the performance tradeoff between stiffness, range-of-motion (RoM), and joint compactness for millimeter-scale notched-tube joints; it increases blocking force without sacrificing RoM. Finite element modeling (FEM) was used to refine design features, and the joint stiffness and RoM are assessed experimentally for three prototypes. The joint is incorporated into a tube-shaft instrument, and the assembled tool's stiffness properties are characterized. The prototype was then assessed in a validated neurosurgical simulator. An individual 1.24-mm outer-diameter notch-tube compliant joint with gear contact-aids is capable of 30 deg maximum bending and can sustain a 0.55 N blocking force with 0.5 mm displacement. A functional instrument shaft with a 15.5- mm-long articulating section was constructed from three joints in series with an external flexible stainless-steel sheath. It achieves a 6.7-mm bending radius at 75 deg maximum bending angle. In preclinical testing with an endoscopic third ventriculostomy and endoscopic tumor biopsy (ETV-ETB) simulator, the tool successfully completes the biopsy and fenestration maneuvers from a single burr-hole entry point. The ANI prototype uses contact-aid geometry incorporated into a compliant nitinol notched-tube joint to produce an articulate biopsy instrument for minimally invasive neurosurgical applications.