Abstract

Wireless capsule endoscopy (WCE) has revolutionized the capacity for evaluation of the gastrointestinal (GI) tract, but its evaluation is limited to the mucosal surface. To overcome this, ultrasound capsule endoscopy (UCE) that can evaluate the deeper structures beyond the mucosal surface has been proposed and several studies focusing on technology development have demonstrated promising results. However, investigations of the potential for clinical utility of this technology are lacking. This work had two main goals: perform ex vivo and in vivo imaging studies in a swine model to (1) evaluate if acoustic coupling between a capsule with a specific size and GI tract can be achieved only through peristalsis autonomously without any human control and (2) identify key issues and challenges to help guide further research. The images acquired in these studies were able to visualize the wall of the GI tract as well as the structures within demonstrating that achieving adequate acoustic coupling through peristalsis is possible. Critical challenges were identified including level of visualization and area of coverage; these require further in-depth investigation before potential clinical utility of UCE technology can be concluded.

References

References
1.
Iddan
,
G.
,
Meron
,
G.
,
Glukhovsky
,
A.
, and
Swain
,
P.
,
2000
, “
Wireless Capsule Endoscopy
,”
Nature
,
405
(
6785
), pp.
417
417
.10.1038/35013140
2.
Gerson
,
L. B.
,
2013
, “
Capsule Endoscopy and Deep Enteroscopy
,”
Gastrointest. Endoscopy
,
78
(
3
), pp.
439
443
.10.1016/j.gie.2013.06.011
3.
Dolak
,
W.
,
Kulnigg-Dabsch
,
S.
, and
Puespoek
,
A.
,
2011
, “
301 Capsule Comparison Study Vienna: IntroMedic®'s MiroCam® Has a Significantly Higher Diagnostic Yield Than Olympus®' Enteropro EndoCapsule® at an Interim Analysis of 30 Patients
,”
Gastrointest. Endoscopy
,
73
(
4
), p.
AB123
.10.1016/j.gie.2011.03.041
4.
Gheorghe
,
C.
,
Iacob
,
R.
, and
Bancila
,
I.
,
2007
, “
Olympus Capsule Endoscopy for Small Bowel Examination
,”
J. Gastrointest. Liver Dis
,
16
(
3
), pp.
309
313
.http://www.jgld.ro/2007/3/11.html
5.
Li
,
C.
,
Zhang
,
B.
,
Chen
,
C.
, and
Li
,
Y.
,
2008
, “
OMOM Capsule Endoscopy in Diagnosis of Small Bowel Disease
,”
J. Zhejiang Univ. Sci. B
,
9
(
11
), pp.
857
862
.10.1631/jzus.B0820034
6.
Ciuti
,
G.
,
Menciassi
,
A.
, and
Dario
,
P.
,
2011
, “
Capsule Endoscopy: From Current Achievements to Open Challenges
,”
IEEE Rev. Biomed. Eng.
,
4
, pp.
59
72
.10.1109/RBME.2011.2171182
7.
Liao
,
Z.
,
Gao
,
R.
,
Xu
,
C.
, and
Li
,
Z.-S.
,
2010
, “
Indications and Detection, Completion, and Retention Rates of Small-Bowel Capsule Endoscopy: A Systematic Review
,”
Gastrointest. Endoscopy
,
71
(
2
), pp.
280
286
.10.1016/j.gie.2009.09.031
8.
Triantafyllou
,
K.
,
Beintaris
,
I.
, and
Dimitriadis
,
G. D.
,
2014
, “
Is There a Role for Colon Capsule Endoscopy Beyond Colorectal Cancer Screening? A Literature Review
,”
World J. Gastroenterol.
,
20
(
36
), pp.
13006
13014
.10.3748/wjg.v20.i36.13006
9.
Biancone
,
L.
,
Onali
,
S.
,
Calabrese
,
E.
,
Petruzziello
,
C.
,
Zorzi
,
F.
,
Condino
,
G.
,
Sica
,
G. S.
, and
Pallone
,
F.
,
2008
, “
Non-Invasive Techniques for Assessing Postoperative Recurrence in Crohn's Disease
,”
Dig. Liver Dis.
,
40
(
Suppl. 2
), pp.
S265
S270
.10.1016/S1590-8658(08)60536-8
10.
Nylund
,
K.
,
Ødegaard
,
S.
,
Hausken
,
T.
,
Folvik
,
G.
,
Lied
,
G. A.
,
Viola
,
I.
,
Hauser
,
H.
, and
Gilja
,
O.-H.
,
2009
, “
Sonography of the Small Intestine
,”
World J. Gastroenterol.
,
15
(
11
), pp.
1319
1330
.10.3748/wjg.15.1319
11.
Parente
,
F.
,
Greco
,
S.
,
Molteni
,
M.
,
Anderloni
,
A.
,
Sampietro
,
G. M.
,
Danelli
,
P. G.
,
Bianco
,
R.
,
Gallus
,
S.
, and
Porro
,
G. B.
,
2004
, “
Oral Contrast Enhanced Bowel Ultrasonography in the Assessment of Small Intestine Crohn's Disease. A Prospective Comparison With Conventional Ultrasound, X Ray Studies, and Ileocolonoscopy
,”
Gut
,
53
(
11
), pp.
1652
1657
.10.1136/gut.2004.041038
12.
Correia
,
J.
,
2009
, “
TROY Endoscope Capsule Using Ultrasound Technology Final Periodic Activity Report
,” IAITI, SA, Matosinhos, Portugal, Project No. 033110.
13.
Cox
,
B. F.
,
Stewart
,
F.
,
Lay
,
H.
,
Cummins
,
G.
,
Newton
,
I. P.
,
Desmulliez
,
M. P. Y.
,
Steele
,
R. J. C.
,
Näthke
,
I.
, and
Cochran
,
S.
,
2017
, “
Ultrasound Capsule Endoscopy: Sounding Out the Future
,”
Ann. Trans. Med.
,
5
(
9
), pp.
201
201
.10.21037/atm.2017.04.21
14.
Lay
,
H. S.
,
Qiu
,
Y.
,
Al-Rawhani
,
M.
,
Beeley
,
J.
,
Poltarjonoks
,
R.
,
Seetohul
,
V.
,
Cumming
,
D.
,
Cochran
,
S.
,
Cummins
,
G.
,
Desmulliez
,
M. P. Y.
,
Wallace
,
M.
,
Trolier-McKinstry
,
S.
,
McPhillips
,
R.
,
Cox
,
B. F.
, and
Demore
,
C. E. M.
,
2016
, “
Progress Towards a Multi-Modal Capsule Endoscopy Device Featuring Microultrasound Imaging
,”
IEEE International Ultrasonics Symposium
(
IUS
), Tours, France, Sept. 18–21, pp.
1
4
.10.1109/ULTSYM.2016.7728692
15.
Lee
,
J. H.
,
Traverso
,
G.
,
Schoellhammer
,
C. M.
,
Blankschtein
,
D.
,
Langer
,
R.
,
Thomenius
,
K. E.
,
Boning
,
D. S.
, and
Anthony
,
B. W.
,
2014
, “
Towards Wireless Capsule Endoscopic Ultrasound (WCEU)
,”
IEEE International Conference on Ultrasonics Symposium
(
IUS
), Chicago, IL, Sept. 3–6, pp.
734
737
.10.1109/ULTSYM.2014.0181
16.
Boysen
,
M.
, and
Ritter
,
M.
,
2010
, “
Small Bowel Obstruction From Capsule Endoscopy
,”
West J. Emerg. Med.
,
11
(
1
), pp.
71
73
.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850858/
17.
Cave
,
D.
,
Legnani
,
P.
,
de Franchis
,
R.
, and
Lewis
,
B. S.
, and
ICCE
,
2005
, “
ICCE Consensus for Capsule Retention
,”
Endoscopy
,
37
(
10
), pp.
1065
1067
.10.1055/s-2005-870264
18.
Mishkin
,
D. S.
,
Chuttani
,
R.
,
Croffie
,
J.
,
DiSario
,
J.
,
Liu
,
J.
,
Shah
,
R.
,
Somogyi
,
L.
,
Tierney
,
W.
,
Wong Kee Song
,
L. M.
, and
Petersen
,
B. T.
,
2006
, “
ASGE Technology Status Evaluation Report: Wireless Capsule Endoscopy
,”
Gastrointest. Endoscopy
,
63
(
4
), pp.
539
545
.10.1016/j.gie.2006.01.014
19.
Velitchkov
,
N. G.
,
Grigorov
,
G. I.
,
Losanoff
,
J. E.
, and
Kjossev
,
K. T.
,
1996
, “
Ingested Foreign Bodies of the Gastrointestinal Tract: Retrospective Analysis of 542 Cases
,”
World J. Surg.
,
20
(
8
), pp.
1001
1005
.10.1007/s002689900152
20.
Lay
,
H. S.
,
Seetohul
,
V.
,
Cox
,
B.
,
Demore
,
C. E. M.
, and
Cochran
,
S.
,
2014
, “
Design and Simulation of a High-Frequency Ring-Shaped Linear Array for Capsule Ultrasound Endoscopy
,”
IEEE International Conference on Ultrasonics Symposium
(
IUS
), Chicago, IL, Sept. 3–6, pp.
683
686
.10.1109/ULTSYM.2014.0168
21.
Lay
,
H. S.
,
Cox
,
B. F.
,
Seetohul
,
V.
,
Démoré
,
C. E. M.
, and
Cochran
,
S.
,
2018
, “
Design and Simulation of a Ring-Shaped Linear Array for Microultrasound Capsule Endoscopy
,”
IEEE Trans. Ultrason., Ferroelectr., Freq. Control
,
65
(
4
), pp.
589
599
.10.1109/TUFFC.2018.2794220
22.
Memon
,
F.
,
Touma
,
G.
,
Wang
,
J.
,
Baltsavias
,
S.
,
Moini
,
A.
,
Chang
,
C.
,
Rasmussen
,
M. F.
,
Nikoozadeh
,
A.
,
Choe
,
J. W.
,
Olcott
,
E.
,
Jeffrey
,
R. B.
,
Arbabian
,
A.
, and
Khuri-Yakub
,
B. T.
,
2016
, “
Capsule Ultrasound Device: Further Developments
,”
IEEE International Ultrasonics Symposium
(
IUS
), Tours, France, Sept. 18–21, pp.
1
4
.10.1109/ULTSYM.2016.7728851
23.
Wang
,
X.
,
Seetohul
,
V.
,
Chen
,
R.
,
Zhang
,
Z.
,
Qian
,
M.
,
Shi
,
Z.
,
Yang
,
G.
,
Mu
,
P.
,
Wang
,
C.
,
Huang
,
Z.
,
Zhou
,
Q.
,
Zheng
,
H.
,
Cochran
,
S.
, and
Qiu
,
W.
,
2017
, “
Development of a Mechanical Scanning Device With High-Frequency Ultrasound Transducer for Ultrasonic Capsule Endoscopy
,”
IEEE Trans. Med. Imaging
,
36
(
9
), pp.
1922
1929
.10.1109/TMI.2017.2699973
24.
Lay
,
H. S.
,
Cummins
,
G.
,
Cox
,
B. F.
,
Qiu
,
Y.
,
Turcanu
,
M. V.
,
McPhillips
,
R.
,
Connor
,
C.
,
Gregson
,
R.
,
Clutton
,
E.
,
Desmulliez
,
M. P. Y.
, and
Cochran
,
S.
,
2019
, “
In-Vivo Evaluation of Microultrasound and Thermometric Capsule Endoscopes
,”
IEEE Trans. Biomed. Eng.
,
66
(
3
), pp.
632
639
.10.1109/TBME.2018.2852715
You do not currently have access to this content.