Detection and capture of circulating tumor cells (CTCs) with microfluidic chips hold significance in cancer prognosis, diagnosis, and anti-cancer treatment. The counting of CTCs provides potential tools to evaluate cancer stages as well as treatment progress. However, facing the challenge of rareness in blood, the precise enumeration of CTCs is challenging. In the present research, we designed an inertial-deformability hybrid microfluidic chip using a long spiral channel with trapezoid-circular pillars and a capture zone. To clinically validate the device, the microfluidic chip has been tested for the whole blood and lysed blood with a small number of CTCs (colorectal and nonsmall-cell lung cancer) spiked in. The capture efficiency reaches over 90% for three types of cancer cell lines at the flow rate of 1.5 mL/h. Following numerical modeling was conducted to explain the working principle and working condition (Reynolds number below 10 and Dean number around 1). This design extended the effective capture length, improved the capture efficiency, and made the CTC enumeration much easier. We believe that this hybrid chip is promising clinically in the CTCs enumeration, evaluation of cancer therapy, and pharmacological responses.
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December 2018
Research-Article
An Inertia-Deformability Hybrid Circulating Tumor Cell Chip: Design, Clinical Test, and Numerical Analysis Available to Purchase
Hongmei Chen,
Hongmei Chen
School of Mathematics and Physics
of Science and Engineering,
Anhui University of Technology,
Maanshan 243002, China;
of Science and Engineering,
Anhui University of Technology,
Maanshan 243002, China;
Division of Nanobionic Research,
Suzhou Institute of Nano-Tech
and Nano-Bionics,
Chinese Academy of Sciences,
Suzhou 215123, Jiangsu, China
Suzhou Institute of Nano-Tech
and Nano-Bionics,
Chinese Academy of Sciences,
Suzhou 215123, Jiangsu, China
Search for other works by this author on:
Zhifeng Zhang
Zhifeng Zhang
Mem. ASME
Department of Engineering Science
and Mechanics,
The Pennsylvania State University,
State College, PA 16802
e-mails: [email protected];
[email protected]
Department of Engineering Science
and Mechanics,
The Pennsylvania State University,
State College, PA 16802
e-mails: [email protected];
[email protected]
Search for other works by this author on:
Hongmei Chen
School of Mathematics and Physics
of Science and Engineering,
Anhui University of Technology,
Maanshan 243002, China;
of Science and Engineering,
Anhui University of Technology,
Maanshan 243002, China;
Division of Nanobionic Research,
Suzhou Institute of Nano-Tech
and Nano-Bionics,
Chinese Academy of Sciences,
Suzhou 215123, Jiangsu, China
Suzhou Institute of Nano-Tech
and Nano-Bionics,
Chinese Academy of Sciences,
Suzhou 215123, Jiangsu, China
Zhifeng Zhang
Mem. ASME
Department of Engineering Science
and Mechanics,
The Pennsylvania State University,
State College, PA 16802
e-mails: [email protected];
[email protected]
Department of Engineering Science
and Mechanics,
The Pennsylvania State University,
State College, PA 16802
e-mails: [email protected];
[email protected]
1Corresponding author.
Manuscript received February 13, 2018; final manuscript received July 16, 2018; published online September 21, 2018. Assoc. Editor: Yaling Liu.
J. Med. Devices. Dec 2018, 12(4): 041004 (6 pages)
Published Online: September 21, 2018
Article history
Received:
February 13, 2018
Revised:
July 16, 2018
Citation
Chen, H., and Zhang, Z. (September 21, 2018). "An Inertia-Deformability Hybrid Circulating Tumor Cell Chip: Design, Clinical Test, and Numerical Analysis." ASME. J. Med. Devices. December 2018; 12(4): 041004. https://doi.org/10.1115/1.4040986
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