Vacuum-assisted biopsy (VAB) technology is designed to provide large-core breast tissue samples that improve the accuracy of breast cancer diagnosis. Using a more sophisticated cutting method (i.e., rotational cutting) than traditional tools, this technology is capable of removing tougher tissue, such as calcifications. However, this technology still has shortcomings and limitations. Tiny tissue samples and unsuccessful sampling have been reported in Ref. [1]. In some of the reported cases, the biopsy cutting mechanism was not strong enough to traverse through dense tissue. In other instances, tiny tissue samples were obtained when sampling very soft tissue, such as adipose tissue. Occasionally, a “dry tap” occurred, which indicates that the tissue sample is not fully separated from the breast. As a result, zero tissue volume is retrieved in the sampling sequence. In the event of any of these issues, the patient must undergo a rebiopsy. Understanding the device–tissue interaction during...

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