Chemical ablations (CHAs) have become an active area of research. Although still in the investigational stage, CHAs offer low cost procedure with significantly lower preparation and procedure times as compared to other ablation modalities. Although numerous human and animal studies have been performed, feasibility, predictability, repeatability, and reproducibility of tissue necrosis as a result of needle injections still remain to be better understood and characterized. CHA is considered as a nonsurgical technique that uses chemical agents at lethal concentrations that are directly injected into the target tissue site to induce desired ablations. Its proposed mechanisms of action are by denaturing proteins, creating focal tissue damage, and ultimately leading to sustained tissue necrosis at the site of injection. We describe here the methodology to quantify the relative amounts of tissue damage/necrosis as a result of CHA so that: (1) injected dose can be optimized; (2) collateral...

Reference

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Singal
,
A.
,
Soule
,
C. L.
,
Ballard
,
J. R.
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Cressman
,
N. K.
, and
Iaizzo
,
P. A.
,
2014
, “
Physiological Tissue Response to Various Ablative Modalities
,”
ASME J. Med. Devices
,
8
(
2
), p.
020906
.
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