The performance of current bioprosthesis designs has traditionally been evaluated on conventional parameters, such as transvalvular pressure drop, effective orifice area, paravalvular leakage, and Reynolds shear stress levels [1]. Although the well-established trileaflet design has been clinically proven to have long-term durability [2] and low levels of thromboembolism [3], recent studies have suggested that the implantation of an artificial valve at the mitral position significantly alters left ventricle flow field [4–6].

The well-established and clinically approved [7] trileaflet epic valve is employed in this study as a control in order to provide a standard at which the hemodynamic performance of the novel bileaflet bioprosthesis can be compared.

The GD valve is a novel bileaflet bioprosthesis (Fig. 1) fabricated from porcine pericardium fixed in 0.625% glutaraldehyde solution [8] overnight and subsequently...

References

References
1.
Bach
,
D. S.
,
1997
, “Stress Echocardiography for Evaluation of Hemodynamics: Valvular Heart Disease, Prosthetic Valve Function, and Pulmonary Hypertension,”
Prog. Cardiovasc. Dis.
,
39
(
6
), pp.
543
554
.
2.
Valfre
,
C.
,
Lus
,
P.
,
Giuseppe
,
M.
,
Salvador
,
L.
,
Bottio
,
T.
,
Cesari
,
F.
,
Rizzoli
,
G.
, and
Gerosa
,
G.
,
2010
, “The Fate of Hancock II Porcine Valve Recipients 25 Years After Implant,”
Eur. J. Cardiothorac. Surg.
,
38
(
2
), pp.
141
145
.
3.
Magilligan
,
D. J.
, Jr.
,
Lewis
,
J. W.
, Jr.
,
Tilley
,
B.
, and
Peterson
,
E.
,
1985
, “The Porcine Bioprosthetic Valve: Twelve Tears Later,”
J. Thorac. Cardiovasc. Surg.
,
89
(4), pp.
499
507
.
4.
Faludi
,
R.
,
Szulik
,
M.
,
D'Hooge
,
J.
,
Herijgers
,
P.
,
Rademakers
,
F.
,
Pedrizzetti
,
G.
, and
Voigt
,
J. U.
,
2010
, “Left Ventricular Flow Patterns in Healthy Subjects and Patients With Prosthetic Mitral Valves: An In Vivo Study Using Echocardiographic Particle Image Velocimetry,”
J. Thorac. Cardiovasc. Surg.
,
139
(
6
), pp.
1501
1510
.
5.
Pedrizzetti
,
G.
,
Domenichini
,
F.
, and
Tonti
,
G.
,
2010
, “On the Left Ventricular Vortex Reversal After Mitral Valve Replacement,”
Ann. Biomed. Eng.
,
38
(
3
), pp.
769
773
.
6.
Pierrakos
,
O.
, and
Vlachos
,
P. P.
,
2006
, “The Effect of Vortex Formation on Left Ventricular Filling and Mitral Valve Efficiency,”
ASME J. Biomech. Eng.
,
128
(
4
), pp.
527
539
.
7.
Jamieson
,
W. R. E.
,
Lewis
,
C. T. P.
,
Sakwa
,
M. P.
,
Cooley
,
D. A.
,
Kshettry
,
V. R.
,
Jones
,
K. W.
,
David
,
T. E.
,
Sullivan
,
J. A.
,
Fradet
,
G. J.
, and
Bach
,
D. S.
,
2011
, “St Jude Medical Epic Porcine Bioprosthesis: Results of the Regulatory Evaluation,”
J. Thorac. Cardiovasc. Surg.
,
141
(
6
), pp.
1449
1454
.
8.
Shen
,
M.
,
Carpentier
,
S. M.
,
Cambillau
,
M.
,
Chen
,
L.
,
Martinet
,
B.
, and
Carpentier
,
A.
,
2001
, “Protein Adsorption in Glutaraldehyde-Preserved Bovine Pericardium and Porcine Valve Tissues,”
Ann. Thorac. Surg.
,
71
(
5
), pp.
S408
S409
.
You do not currently have access to this content.