Naegleria fowleri is a free-living amoeba; it is a protist pathogen that is known to cause a fatal encephalitis in humans known as “primary amoebic meningoencephalitis” (PAM). The peak season for the cases admitted to the hospital is in the summers, and all the reported cases have a history of exposure to the warm waters. Mostly, PAM is reported in recent swimmers and people who perform ablution and/or nasal cleansing. Much has been done for vaccination and treatment without any success in past 60 years, but the mortality has remained 99%. Here, we propose a prophylaxis for this disease by introducing a device “Naegleriopel.” This device is noninvasive and requires insertion into the nostrils at times of swimming or water sports related activities. This device, made up of synthetic plastic or silicone, could be adapted to the contours of the interior of the nose. It is expected to reduce the sporadic and seasonal incidences of PAM.

References

References
1.
Schuster
,
F. L.
, and
Visvesvara
,
G. S.
,
2004
, “
Free-Living Amoebae as Opportunistic and Non-Opportunistic Pathogens of Humans and Animals
,”
Int. J. Parasitol.
,
34
(
9
), pp.
1001
1027
.
2.
Visvesvara
,
G. S.
,
2010
, “
Amoebic Meningoencephalitis and Keratitis: Challenges in Diagnosis and Treatment
,”
Curr. Opin. Infect Dis.
,
23
(
6
), pp.
590
594
.
3.
Baig
,
A. M.
, and
Khan
,
N. A.
,
2015
, “
Tackling Infection Owing to Brain-Eating Amoeba
,”
Acta Trop.
,
142
, pp.
86
88
.
4.
Kim
,
J. H.
,
Sohn
,
H. J.
,
Lee
,
J.
,
Yang
,
H. J.
,
Chwae
,
Y. J.
,
Kim
,
K.
,
Park
,
S.
, and
Shin
,
H. J.
,
2013
, “
Vaccination With Lentiviral Vector Expressing the nfa1 Gene Confers a Protective Immune Response to Mice Infected With Naegleria fowleri
,”
Clin. Vaccine Immunol.
,
20
(
7
), pp.
1055
1060
.
5.
Baig
,
A. M.
, and
Khan
,
N. A.
,
2014
, “
Novel Chemotherapeutic Strategies in the Management of Primary Amoebic Meningoencephalitis Due to Naegleria fowleri
,”
CNS Neurosci Ther.
,
20
(
3
), pp.
289
290
.
6.
Baig
,
A. M.
,
Kulsoom
,
H.
, and
Khan
,
N. A.
,
2014
, “
Primary Amoebic Meningoencephalitis: Amoebicidal Effects of Clinically Approved Drugs Against Naegleria fowleri
,”
J. Med. Microbiol.
,
63
(Pt
5
), pp.
760
762
.
7.
Kemble
,
S. K.
,
Lynfield
,
R.
,
DeVries
,
A. S.
,
Drehner
,
D. M.
,
Pomputius
,
W. F.
, III
,
Beach
,
M. J.
,
Visvesvara
,
G. S.
,
da Silva
,
A. J.
,
Hill
,
V. R.
,
Yoder
,
J. S.
,
Xiao
,
L.
,
Smith
,
K. E.
, and
Danila
,
R.
,
2012
, “
Fatal Naegleria fowleri Infection Acquired in Minnesota: Possible Expanded Range of a Deadly Thermophilic Organism
,”
Clin. Infect. Dis.
,
54
(
6
), pp.
805
809
.
8.
Baig
,
A. M.
,
2015
, “
Pathogenesis of Amoebic Encephalitis: Are the Amoebae Being Credited to an ‘Inside Job’ Done by the Host Immune Response?
,”
Acta Trop.
,
148
, pp.
72
76
.
9.
CDC
, 2010, “
Swimming Prevention and Control
,” Centers for Disease Control and Prevention, Atlanta, GA, http://www.cdc.gov/parasites/naegleria/swimming.html, accessed Sept. 13,
2015
.
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