Infilling strategies have been proposed for decades and are widely used in engineering problems. It is still challenging to achieve an effective trade-off between global exploration and local exploitation. In this paper, a novel decision-making infilling strategy named the Go-inspired hybrid infilling (Go-HI) strategy is proposed. The Go-HI strategy combines multiple individual infilling strategies, such as the mean square error (MSE), expected improvement (EI), and probability of improvement (PoI) strategies. The Go-HI strategy consists of two major parts. In the first part, a tree-like structure consisting of several subtrees is built. In the second part, the decision value for each subtree is calculated using a cross-validation (CV)-based criterion. Key factors that significantly influence the performance of the Go-HI strategy, such as the number of component infilling strategies and the tree depth, are explored. Go-HI strategies with different component strategies and tree depths are investigated and also compared with four baseline adaptive sampling strategies through three numerical functions and one engineering case. Results show that the number of component infilling strategies exerts a larger influence on the global and local performance than the tree depth; the Go-HI strategy with two component strategies performs better than the ones with three; the Go-HI strategy always outperforms the three component infilling strategies and the other four benchmark strategies in global performance and robustness and saves much computational cost.