This editorial from the guest editors introduces the special issue dedicated to the centennial celebration of the ASME Manufacturing Engineering Division. Guest authors were invited to present a review of research performed over the past 25 years (since the MED semisesquicentennial celebratory issue) in key research areas such as machining, abrasive processing, control, biological manufacturing, and artificial intelligence applied to manufacturing. These review papers should provide researchers with a wide-ranging view of the state of the art in a number of areas, and help to define future research directions.

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