Based on the propagation theory of blast waves and the strain rate effect of polyurea, the explosion-proof performance of polyurea-reinforced masonry walls with different spraying methods is discussed in this paper. The impact fracture of masonry walls after contact explosion was analyzed, and the fracture results of a blast wave on polyurea-reinforced masonry walls with different spraying methods were predicted. Furthermore, explosion-proof experiments of a standard masonry wall (2m×1.2m×0.37m) under three conditions including non-sprayed, back surface sprayed polyurea and double-sided sprayed polyurea were carried out to verify the theoretical predictions. Finally, the impact fracture results of standard masonry walls after a 1 kg TNT contact explosion under the three conditions were obtained. The test results were in good agreement with the theoretical predictions. It clearly demonstrated that polyurea coating can significantly improve the explosion-proof performance of masonry walls, and double-sided sprayed showed better explosion-proof performance than back surface sprayed at the same coating thickness.