The loop heat pipe (LHP) is a passive heat sink used in aerospace and electronic devices. As the core component of the LHP, the physical property parameters of porous wick directly affect the overall performance of the LHP. In this paper, the performance of the porous wick is improved by adjusting the pore size, thereby improving the performance of the LHP. The nickel-based double-pore porous wicks are prepared by T225 nickel powder and NaCl particles, and the pore size of the porous wicks can be changed by different cold pressing pressures (30KN, 40KN, 50KN, 60KN). The effects of different cold pressing pressures on the porosity, permeability, and other physical property parameters are studied when the ratio of pore former is 20wt%. In the end, we select the cold pressing pressure of 30KN to prepare the porous wick of the LHP. Then the effects of constant load and variable load of the heat transfer performance under different placement angles are studied. The results show that the heat load range is 10W-100W, the minimum evaporator thermal resistance is 0.424K/W, and the minimum LHP thermal resistance is 0.598K/W. When ß=0°, there is a "backflow" phenomenon at the initial stage of low thermal load. With the increase of thermal load, the "backflow" duration decreases until it disappears, and the start-up time becomes shorter. The thermal resistances of the evaporator and LHP decrease and then increase. When ß= -90°, the LHP appears "reverse start-up" phenomenon.