This paper investigates the augmentation of heat transfer during pool boiling in a novel aqueous binary mixture of surfactants. The surfactants used were Sodium Dodecyl Sulphate (anionic), Centrimonium Bromide (cationic), and Nicotine (non-ionic). The aqueous binary mixtures SDS-CTAB, CTAB- Nicotine, and SDS-Nicotine were prepared on the volume percentage basis. The augmentation was investigated by studying a single bubble growth in an aqueous binary mixture of surfactants. The investigation was conducted at two values of heat fluxes to probe the effect of heat flux on bubble growth. A reduction in surface tension was attained by SDS-CTAB, CTAB-Nicotine, and SDS-Nicotine aqueous binary systems compared to its individual aqueous surfactant solutions at their optimum concentrations. The most significant surface tension result was obtained by the novel SDS-Nicotine aqueous binary system at 25:75 volume percentages. A decrement in the bubble departure diameter and an increment in the release frequency were observed for SDS-Nicotine aqueous binary system both heat fluxes. The boiling heat transfer coefficient of SDS-Nicotine aqueous binary system was found to be increased by 36.32% and 58.67% compared to saturated water at low and high heat flux, respectively.