The heat transfer coefficient of cylindrical holes fed by varying internal cross-flow channels with different cross-flow Reynolds numbers Rec is experimentally studied on a low-speed flat-plate facility. Three coolant cross flow cases, including a smooth case and two ribbed cases with 45/135-deg ribs, are studied at Rec = 50,000, and 100,000 with varying blowing ratios M of 0.5, 1.0, and 2.0. A transient liquid-crystal (LC) measurement technique is used to determine the heat transfer coefficient. At lower M, the heat transfer enhancement regions are asymmetrical for the smooth and 45-deg cases. The asymmetrical vortex is more pronounced with increasing cross-flow direction velocity, resulting in a more skewed distribution at Rec = 100,000. Conversely, the contours are laterally symmetric in the 135-deg case at varying Rec. A fork-shaped trend with a relatively high heat transfer coefficient appears upstream, and the increases in the heat transfer in the 135-deg cases are lower than those in the 45-deg cases. As M increases to 2.0, the vortex intensity increases, resulting in a stronger scouring effect upstream, especially at large Rec. The range and degree are affected by Rec at M = 2.0. The core of the heat transfer enhancement is skewed to the −Y side for both cases.