This paper aims to investigate the entropy generation in slip flow due to double rotating disks. Heat equation is formulated by considering effects of viscous dissipation, Joule heating and nonlinear thermal radiation. Brownian motion and thermophoresis effects of nanofluid are also discussed. Applied magnetic field is considered to be time dependent. Homogeneous–heterogeneous reactions are also studied. Von Karman transformations are used. Homotopy analysis method is implemented on system of equations for convergent series solutions. Influence of various flow parameters on entropy, Bejan number, velocity, temperature, Nusselt number, and skin friction is discussed through graphs and tables. Axial velocity decays for higher nonlinear mixed convection variable of temperature and velocity slip parameter. Temperature rises for larger thermal slip parameter and thermophoresis parameter. Entropy and Bejan number are increasing for higher estimation of homogeneous reaction parameter and diffusion parameters.