A model is presented to calculate nucleate boiling heat transfer coefficients of binary mixtures. The model includes the governing physical phenomena, such as the variation of the phase interface curvature, the adhesion pressure between wall and liquid, the interfacial thermal resistance as well as the local variation of composition and liquid-vapor equilibrium. Marangoni convection is considered, too. The theoretical background of these phenomena is described and their implementation is explained. The model is verified by comparing calculated heat transfer coefficients of hydrocarbon mixtures with experimental data. Computational and experimental data are in good agreement. In the examples a considerable amount of the total heat flow passes through a tiny thin film area, called micro region, where the liquid-vapor phase interface is attached to the wall. Very high spatial gradients of heat flux and mixture concentration occur interacting with overall heat transfer performance.