This work presents fully coupled computational fluid dynamics (CFD) simulations and thermodynamic cycle analyses of a small-scale turbojet engine at several conditions along the equilibrium running line. The CFD simulations use a single mesh for the entire engine, from the intake to the exhaust, allowing information to travel in all directions. The CFD simulations are performed along the equilibrium running line by using the iterative Secant method to compute the fuel flow rate required to match the compressor and turbine power. The freestream pressure and temperature and shaft angular speed are the only inputs needed for the CFD simulations. To evaluate the consistency of the CFD results with thermodynamic cycle results, outputs from the CFD simulations are prescribed as inputs to the cycle model. This approach enables on-design and off-design cycle calculations to be performed without requiring turbomachinery performance maps. In contrast, traditional off-design cycle analyses require either scaling, calculating, or measuring compressor and turbine maps with boundary condition assumptions. In addition, the CFD simulations and the cycle analyses are compared with measurements of the turbojet engine. The CFD simulations, thermodynamic cycle analyses, and measurements agree in terms of total temperature and pressure at the diffuser–combustor interface, air and fuel mass flow rate, equivalence ratio, and thrust. The developed methods to perform CFD simulations from the intake to the exhaust of the turbojet engine are expected to be useful for guiding the design and development of future small-scale gas turbine engines.