The blisk design of the wheel with cooled blades is developed on the basis of the turbine wheel with a detachable connection of the blades with the disk. The blades of the blisk are produced from casting heat-resistant nickel alloy. The disk portion is created from granulated alloy with different grain sizes along the disk radius. The system of supplying cooling air in the blades of the wheel is developed. The technology of manufacturing a disk consisting of granules of various sizes and technology of connection of a disk with cooled cast blades is developed. To determine the mechanical characteristics of the zones of connection of dissimilar materials, samples were tested. Multiparameter optimization of the blisk was carried out. The mass of the designed wheel was reduced by more than 40% compared to the original wheel with lock connection when the strength and service life conditions were satisfied.