Abstract

Infectious microorganisms are important to multiple communities engaged in biodefense and biosecurity, including the agencies responsible for health, defense, law enforcement, agriculture, and drug and food safety. Many agencies have created lists of high priority infectious microorganisms to prioritize research efforts or to formally control the possession and distribution of specific organisms or toxins. However, the biological classification of infectious microorganisms is often complex and ambiguous, leading to uncertainty and confusion for scientists involved in biosecurity work. To address this problem, we created a database, known as the Microbial Rosetta Stone, which resolves many of these ambiguities and includes links to additional information on the microbes, such as gene sequence data and scientific literature. Here we discuss the efforts to coordinate organism names from pathogen lists from various governmental agencies according to biological relatedness and show the overlap of high-priority organisms from multiple agencies. To our knowledge, this is the first comprehensive coordination of pathogens, synonyms, and correct taxonomic names. The organized tables and visual aids are freely available at http://www.microbialrosettastone.com. This website provides a single location where access to information on a broad range of disease-causing organisms and toxins is available to members of the biosecurity community.

References

1.
Budowle
B
,
Schutzer
SE
,
Einseln
A
,
Kelley
LC
,
Walsh
AC
,
Smith
JA
, et al
.
Public health. Building microbial forensics as a response to bioterrorism
. Science
26
09
2003
;
301
(
5641
):
1852
3
.
2.
The NCBI Taxonomy Homepage
. Available at: http://www.ncbi.nlm.nih.gov/Taxonomy/tax.html.
3.
NCBI
. Available at: http://www.ncbi.nlm.nih.gov/.
4.
Wheeler
DL
,
Church
DM
,
Federhen
S
,
Bryant
SH
,
Canese
K
,
Church
DM
, et al
.
Database resources of the National Center for Biotechnology
.
Nucleic Acids Res
 0305-1048
01
01
2003
;
31
(
1
):
28
3
.
5.
The Institute for Genomics Research
. Available at: http://www.tigr.org.
6.
Tree of Life Web Project
. Available at: http://tolweb.org/tree/.
7.
Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research
. Available at: http://rce.swmed.edu/biot/ biot.htm.
8.
Iyer
LM
,
Aravind
L
,
Koonin
EV
.
Common origin of four diverse families of large eukaryotic DNA viruses
.
J Virol
 0022-538X
2001
;
75
:
11720
34
.
9.
CDC Select Agent Program
. Available at: http://www.cdc.gov/od/sap/.
10.
APHIS Agricultural Select Agent Program
. Available at: http://www. aphis.usda.gov/program/ag_ selectagent/index.html.
11.
12.
Fauci
AS
.
NIAID strategic plan for biodefense research
: Bethesda, MD: National Institute of Allergy and Infectious Diseases,
02
2002
; NIH Publication No. 03-5306.
13.
National Institute of Allergy and Infectious Diseases.
NIAID biodefense research agenda for CDC category A agents
. Bethesda, MD: National Institute of Allergy and Infectious Diseases,
02
2002
; NIH Publication No. 03-5308.
14.
National Institute of Allergy and Infectious Diseases.
NIAID biodefense research agenda for CDC category B and C priority pathogens
. Bethesda, MD: National Institute of Allergy and Infectious Diseases,
2003
.
15.
Greenwood
DP
.
A relative assessment of putative biological-warfare agents
.
Lexington, MA
:
Massachusetts Institute of Technology
;
17
07
1997
; ESC-TR-97-054.
16.
Kortepeter
MG
,
Parker
GW
.
Potential biological weapons threats
.
Emerging Infect Dis
 1080-6040
1999
;
5
(
4
):
523
7
.
17.
WHO:
Communicable Disease Surveillance & Response (CSR)
. Available at: http://www.who.int/csr/disease/en/.
18.
Gibbs
MJ
,
Koga
R
,
Moriyama
H
,
Pfeiffer
P
,
Fukuhara
T
.
Phylogenetic analysis of some large double-stranded RNA replicons from plants suggests they evolved from a defective single-stranded RNA virus
.
J Gen Virol
 0022-538X
2000
;
81
:
227
33
.
This content is only available via PDF.
You do not currently have access to this content.