Abstract
Sir: Thank you for the comments regarding our article A fatal drug interaction between oxycodone and clonazepam. The commentary states that the authors seem to base their statement of a fatal drug interaction on a metabolic interaction between oxycodone and clonazepam. The second paragraph of the introductory section postulates not only mechanisms of metabolic hindrance by competitive substrates (clonazepam and oxycodone), but also by other drugs (cannabinoids) and pathologies present in this particular subject. In our conclusions, we also state the concentrations of oxycodone and clonazepam observed may have resulted from either an acute administration of a particular dosage and/or an attenuated metabolism.
Issue Section:
Article
References
1.
Ghosh
SK
, Poddar
MK
. Effect of delta-9-tetrahydrocannabinol and theophylline on hepatic microsomal drug metabolizing enzymes
. Biochem Pharmacol
0006-2952 17
11
1992
;44
(10
):2021
–7
.2.
Hardman
JG
, Limbird
LE
, editors, Goodman and Gilman's the pharmacological basis of therapeutics
. 10th ed. McGraw Hill
, 2001
;406.3.
Quantitative contribution of CYP2D6 and CYP3A4 to oxycodone oxidation in human liver microsomes
. Presented at the American Assoc. of Phar
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