The goal of the study is to identify optimal breakwater designs to be placed on the banks of various water bodies in coastal Louisiana, to prevent the coastal erosion. Coastal erosion is a significant concern for Louisiana's wavy coastline. The loss of coastal wetlands is threatening the environment and the economic development. One of the ways to prevent coastal erosion and wetland losses is by using breakwaters designed to reduce the wave energy and change the transport of sediments brought by the waves. The objective of this research is to analyze the turbulent characteristics around specially designed three-dimensional (3D) breakwaters, and its impact on sediment deposition under coastal wave actions. Both computational fluid dynamics (CFD) simulations and experimental measurements were conducted. In order to validate the CFD models used for this study, the simulation results were compared to data measured from a scale-down experiment. Once the validity of the CFD models has been confirmed on three miniature panels, namely, a solid panel, a panel with three holes, and a panel with eight holes, the simulations were scaled up to the actual size of the designed breakwater panels for tests. The breakwater designs aim to allow sediment pass through the holes, to deposit sediment at target areas, and to reduce wave actions. There were three different panel-design cases simulated in this study. The results of 3D CFD simulations of these panels were compared and analyzed to determine the performance of each design in terms of wave reduction and sediment retention.